Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3775506..3776137 Replicon chromosome
Accession NZ_CP050498
Organism Escherichia coli strain RM13322

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag HCR07_RS19185 Protein ID WP_001259385.1
Coordinates 3775506..3775781 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag HCR07_RS19190 Protein ID WP_000593554.1
Coordinates 3775778..3776137 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCR07_RS19170 3770510..3771577 + 1068 WP_000361467.1 HlyD family secretion protein -
HCR07_RS19175 3771574..3774309 + 2736 WP_000149167.1 ribosome-associated ATPase/putative transporter RbbA -
HCR07_RS19180 3774309..3775433 + 1125 WP_001216257.1 ABC transporter permease -
HCR07_RS19185 3775506..3775781 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
HCR07_RS19190 3775778..3776137 + 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HCR07_RS19195 3776187..3777047 - 861 WP_001131783.1 class II aldolase -
HCR07_RS19200 3777079..3777348 - 270 WP_000933060.1 HPr family phosphocarrier protein -
HCR07_RS19205 3777338..3778846 - 1509 WP_001298718.1 carbohydrate kinase -
HCR07_RS19210 3778839..3780197 - 1359 WP_001298729.1 PTS galactitol transporter subunit IIC -
HCR07_RS19215 3780274..3780555 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
HCR07_RS19220 3780552..3781025 - 474 WP_001161553.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3767889..3776137 8248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T152949 WP_001259385.1 NZ_CP050498:3775506-3775781 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T152949 NZ_CP066641:c22339-22082 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT152949 WP_000593554.1 NZ_CP050498:3775778-3776137 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT152949 NZ_CP066641:c22601-22332 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References