152940

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1489604..1490082 Replicon chromosome
Accession NZ_CP050498
Organism Escherichia coli strain RM13322

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag HCR07_RS08330 Protein ID WP_001303876.1
Coordinates 1489795..1490082 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag HCR07_RS08325 Protein ID WP_000536233.1
Coordinates 1489604..1489795 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCR07_RS08290 1484984..1485754 - 771 WP_000450992.1 DUF1627 domain-containing protein -
HCR07_RS08295 1485836..1486522 - 687 WP_000788749.1 ATP-binding protein -
HCR07_RS08300 1486529..1487644 - 1116 WP_001205820.1 hypothetical protein -
HCR07_RS08305 1487723..1488178 + 456 WP_000273724.1 hypothetical protein -
HCR07_RS08310 1488385..1488810 - 426 WP_000693855.1 Rha family transcriptional regulator -
HCR07_RS08315 1488794..1489066 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
HCR07_RS08320 1489175..1489576 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
HCR07_RS08325 1489604..1489795 + 192 WP_000536233.1 hypothetical protein Antitoxin
HCR07_RS08330 1489795..1490082 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HCR07_RS08335 1490359..1490514 + 156 WP_000379575.1 DUF1391 family protein -
HCR07_RS08340 1490656..1491045 + 390 WP_000394513.1 hypothetical protein -
HCR07_RS08345 1491232..1491417 - 186 WP_001133046.1 hypothetical protein -
HCR07_RS08355 1493258..1493446 + 189 WP_000413705.1 cell division inhibition protein DicB -
HCR07_RS08360 1493443..1493634 + 192 WP_001098307.1 DUF1482 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1481796..1504862 23066


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T152940 WP_001303876.1 NZ_CP050498:1489795-1490082 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T152940 NZ_CP066624:c40932-40810 [Enterococcus faecium]
ATGAAAGGAGTAAGCCTTTTGTCCGCATATGAGACAATTCAAACCATTCTTGGTTTTGGTATGTTTACCATTGCTTTGAT
TAGTTTGATTGTAAATATGCTTAAAAATGACAAAAAGAAATAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT152940 WP_000536233.1 NZ_CP050498:1489604-1489795 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT152940 NZ_CP066624:40727-40828 [Enterococcus faecium]
CCCTCATTAACAGCACCGTTTAAAGAACGGCGGCTCAGATTAATTATTTATTGAGAAATAACCGATCCTCGCTAAAGTGA
CGGTTATTTCTTTTTGTCATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References