Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2204920..2205485 Replicon chromosome
Accession NZ_CP050497
Organism Treponema vincentii strain OMZ 806

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GWP40_RS10025 Protein ID WP_212565222.1
Coordinates 2204920..2205258 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GWP40_RS10030 Protein ID WP_212565223.1
Coordinates 2205252..2205485 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWP40_RS09990 (GWP40_10005) 2200056..2200397 + 342 WP_212565215.1 type II toxin-antitoxin system HicB family antitoxin -
GWP40_RS09995 (GWP40_10010) 2200407..2202650 - 2244 WP_212565216.1 DEAD/DEAH box helicase -
GWP40_RS10000 (GWP40_10015) 2202709..2202969 - 261 WP_212565217.1 Txe/YoeB family addiction module toxin -
GWP40_RS10005 (GWP40_10020) 2202966..2203226 - 261 WP_212565218.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GWP40_RS10010 2203268..2203579 + 312 WP_212565219.1 hypothetical protein -
GWP40_RS10015 (GWP40_10030) 2203954..2204433 - 480 WP_212565220.1 hypothetical protein -
GWP40_RS10020 (GWP40_10035) 2204544..2204822 + 279 WP_212565221.1 helix-turn-helix transcriptional regulator -
GWP40_RS10025 (GWP40_10040) 2204920..2205258 - 339 WP_212565222.1 endoribonuclease MazF Toxin
GWP40_RS10030 (GWP40_10045) 2205252..2205485 - 234 WP_212565223.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GWP40_RS10035 (GWP40_10050) 2205574..2206905 - 1332 WP_212565224.1 ATP-binding protein -
GWP40_RS10040 (GWP40_10055) 2206930..2209842 - 2913 WP_212565225.1 N-6 DNA methylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-111)

Antitoxin

SpoVT-AbrB domain

(6-48)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12715.64 Da        Isoelectric Point: 6.6261

>T152927 WP_212565222.1 NZ_CP050497:c2205258-2204920 [Treponema vincentii]
MVNSNYVPEKGDLVWLDFDPQIGHEQKGRRPAICISHKQYNQKIGLALICPITSHIKGYPFEIVLNGHSISGCILSDQIK
SLDWKQRNCHFIEKAAAEEIDSVVQNIQLMIE

Download         Length: 339 bp

>T152927 NZ_CP066598:519833-520174 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCAGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8584.91 Da        Isoelectric Point: 5.7928

>AT152927 WP_212565223.1 NZ_CP050497:c2205485-2205252 [Treponema vincentii]
MQAVVQKWGNSLGLRIPSFWAKDNDIKNGSTVEVIMEKEKIIILPQKKSLDAMLALVNEENIHSEISTGYAAGKEAW

Download         Length: 234 bp

>AT152927 NZ_CP066598:519603-519833 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References