Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 443788..444422 Replicon chromosome
Accession NZ_CP050497
Organism Treponema vincentii strain OMZ 806

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GWP40_RS02080 Protein ID WP_212565853.1
Coordinates 443788..444192 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GWP40_RS02085 Protein ID WP_212565854.1
Coordinates 444192..444422 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWP40_RS02060 (GWP40_02055) 439706..439963 - 258 WP_212565849.1 SemiSWEET family transporter -
GWP40_RS02065 (GWP40_02060) 440048..441487 - 1440 WP_212565850.1 potassium/proton antiporter -
GWP40_RS02070 (GWP40_02065) 441916..442290 - 375 WP_212565851.1 type II toxin-antitoxin system VapC family toxin -
GWP40_RS02075 (GWP40_02070) 442277..442486 - 210 WP_212565852.1 hypothetical protein -
GWP40_RS13225 442541..442663 - 123 WP_269140250.1 hypothetical protein -
GWP40_RS02080 (GWP40_02075) 443788..444192 - 405 WP_212565853.1 type II toxin-antitoxin system VapC family toxin Toxin
GWP40_RS02085 (GWP40_02080) 444192..444422 - 231 WP_212565854.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GWP40_RS02090 (GWP40_02085) 444770..445879 + 1110 WP_212565855.1 OmpA family protein -
GWP40_RS02100 (GWP40_02095) 446162..447088 + 927 WP_212565856.1 tetratricopeptide repeat protein -
GWP40_RS02105 (GWP40_02100) 447104..447751 + 648 WP_212565857.1 helix-turn-helix transcriptional regulator -
GWP40_RS02110 (GWP40_02105) 447813..448520 + 708 WP_212566510.1 tRNA 2-thiocytidine biosynthesis TtcA family protein -
GWP40_RS02115 (GWP40_02110) 448580..449263 - 684 WP_212565858.1 DNA alkylation repair protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 441916..455609 13693


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15604.97 Da        Isoelectric Point: 8.2512

>T152926 WP_212565853.1 NZ_CP050497:c444192-443788 [Treponema vincentii]
MYLLDTNICIFLIKNKNQHLKKKIFNCKKEELFLSSITIAELEYGVSKSQFREKNRRALLNFCSDFTNIIDFTTEDTEIY
GMIRAYLENKGIPIGPFDTQIAAQSLARNLTVVTNNTREFSRIPGLRVEDWTKE

Download         Length: 405 bp

>T152926 NZ_CP066598:220398-220664 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8682.82 Da        Isoelectric Point: 4.7660

>AT152926 WP_212565854.1 NZ_CP050497:c444422-444192 [Treponema vincentii]
MVCTKVFTSGNSQAVRIPKEFHIDVSELFIKKIGSSIILTPKENNWENLERSLSEFSDDFMAEGRSQPAMQEREGF

Download         Length: 231 bp

>AT152926 NZ_CP066598:220135-220398 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References