Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 341937..342549 Replicon chromosome
Accession NZ_CP050485
Organism Enterococcus gallinarum strain EGM181

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EGM181_RS01915 Protein ID WP_181236084.1
Coordinates 341937..342125 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EGM181_RS01920 Protein ID WP_086339316.1
Coordinates 342163..342549 (+) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGM181_RS01880 337302..338339 + 1038 WP_123864061.1 hypothetical protein -
EGM181_RS01885 338336..338602 + 267 WP_123864060.1 hypothetical protein -
EGM181_RS01890 339264..339638 + 375 WP_123864352.1 plasmid mobilization relaxosome protein MobC -
EGM181_RS01895 339635..341131 + 1497 WP_154731698.1 relaxase/mobilization nuclease domain-containing protein -
EGM181_RS01900 341200..341304 + 105 WP_123864224.1 type II toxin-antitoxin system RelE/ParE family toxin -
EGM181_RS01905 341291..341557 + 267 WP_123864213.1 helix-turn-helix domain-containing protein -
EGM181_RS01910 341576..341845 + 270 WP_154731699.1 antitoxin -
EGM181_RS01915 341937..342125 + 189 WP_181236084.1 type II toxin-antitoxin system HicA family toxin Toxin
EGM181_RS01920 342163..342549 + 387 WP_086339316.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EGM181_RS01925 342718..342972 + 255 WP_181236085.1 hypothetical protein -
EGM181_RS01930 342987..343565 + 579 WP_123864216.1 recombinase family protein -
EGM181_RS01935 343571..344119 - 549 WP_123864217.1 hypothetical protein -
EGM181_RS01940 344181..344471 - 291 WP_123864218.1 hypothetical protein -
EGM181_RS01945 344523..344705 - 183 WP_123864226.1 hypothetical protein -
EGM181_RS01950 345480..345752 + 273 WP_123864219.1 hypothetical protein -
EGM181_RS01955 345745..346005 + 261 WP_123864220.1 hypothetical protein -
EGM181_RS01960 346172..346366 + 195 WP_123864221.1 hypothetical protein -
EGM181_RS01965 346480..346941 + 462 WP_123864222.1 hypothetical protein -
EGM181_RS01970 346983..347413 + 431 Protein_333 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 310121..353213 43092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-62)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-100)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7048.29 Da        Isoelectric Point: 11.0565

>T152911 WP_181236084.1 NZ_CP050485:341937-342125 [Enterococcus gallinarum]
MPMTIREAEKLLKEAGFREVKGGKGSHRKFVKENFPRPVILTSHSKELSKRVEESVRKAVGL

Download         Length: 189 bp

>T152911 NZ_CP066570:c41810-41460 [Enterococcus faecium]
ATGGTGAGAAAACCTAGACAAGGCGATATTCTATTATTGAATACAGCACCTCGATCTGGACACGAACAGACAGGTAAAAG
ACCTTATATTGTTTTAAGTCATGATATTATTGCGGATTATAGTAACGTTGTTACAGTTGCTCCAATTTCTAGTACAACTA
GAAACTATCCGCTATATGTAAATATAAACTCAGAATATGAAATGAAGACAACAGGAAAAGTATTATTAGATCAACTAACG
ACAATTGATTATGAAGCCAGAGAGTGTATTTTTTTGGAAAAAGCGCATGATAGTTTAGTTGAGGAGTTATTGATGAAAGT
TAGAACAGTTTTTCAAAAAGTAAGCAAATAA

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 14235.58 Da        Isoelectric Point: 4.7160

>AT152911 WP_086339316.1 NZ_CP050485:342163-342549 [Enterococcus gallinarum]
MKKVYPAIFEKDPVGYSIFFPDIEGAVTQCENVSEGLEIASDALGIMLGDLVEKNQLLPVPTPINALSLDLDKQFATLVS
VELNDYLKGDQLDKKTIKIPHWLNVRAMNAKINFSKTMAEALEKKLNL

Download         Length: 387 bp

>AT152911 NZ_CP066570:c42067-41804 [Enterococcus faecium]
ATGGAAATGTTACCTATAAAAAAATGGGGAAATAGTAATGGCCTTAGATTGCCAAAGTATATTATGGAATATCTTGGAAT
TCATACAGAAGACAAAGTGAAGATAATACAAGAAGAAGTAAACGGTCAGAAGCGGCTAATTATCGAAGCGGCTAATATAG
AAAATGAATTAACAATTGAACAGTTATTTGAAAATTACACTGATGAAAGAAATCATGTGACGATTCAAAATTTAGGTGAA
GCAGTAGGTAATGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References