Detailed information of TA system TA152910

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicA-epsilon/HicA-epsilon
• Location: 341576..342125
• Replicon: chromosome
• Accession: NZ_CP050485
• Organism: Enterococcus gallinarum strain EGM181

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EGM181_RS01915
• Protein ID: WP_181236084.1
• Coordinates: 341937..342125 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: epsilon
• Uniprot ID: -
• Locus tag: EGM181_RS01910
• Protein ID: WP_154731699.1
• Coordinates: 341576..341845 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGM181_RS01880	337302..338339	+	1038	WP_123864061.1	hypothetical protein	-
EGM181_RS01885	338336..338602	+	267	WP_123864060.1	hypothetical protein	-
EGM181_RS01890	339264..339638	+	375	WP_123864352.1	plasmid mobilization relaxosome protein MobC	-
EGM181_RS01895	339635..341131	+	1497	WP_154731698.1	relaxase/mobilization nuclease domain-containing protein	-
EGM181_RS01900	341200..341304	+	105	WP_123864224.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EGM181_RS01905	341291..341557	+	267	WP_123864213.1	helix-turn-helix domain-containing protein	-
EGM181_RS01910	341576..341845	+	270	WP_154731699.1	antitoxin	Antitoxin
EGM181_RS01915	341937..342125	+	189	WP_181236084.1	type II toxin-antitoxin system HicA family toxin	Toxin
EGM181_RS01920	342163..342549	+	387	WP_086339316.1	type II toxin-antitoxin system HicB family antitoxin	-
EGM181_RS01925	342718..342972	+	255	WP_181236085.1	hypothetical protein	-
EGM181_RS01930	342987..343565	+	579	WP_123864216.1	recombinase family protein	-
EGM181_RS01935	343571..344119	-	549	WP_123864217.1	hypothetical protein	-
EGM181_RS01940	344181..344471	-	291	WP_123864218.1	hypothetical protein	-
EGM181_RS01945	344523..344705	-	183	WP_123864226.1	hypothetical protein	-
EGM181_RS01950	345480..345752	+	273	WP_123864219.1	hypothetical protein	-
EGM181_RS01955	345745..346005	+	261	WP_123864220.1	hypothetical protein	-
EGM181_RS01960	346172..346366	+	195	WP_123864221.1	hypothetical protein	-
EGM181_RS01965	346480..346941	+	462	WP_123864222.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	310121..353213	43092

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-62)

Antitoxin

• Bacterial epsilon antitoxin (3-88)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7048.29 Da
• Isoelectric Point: 11.0565

>T152910 WP_181236084.1 NZ_CP050485:341937-342125 [Enterococcus gallinarum]
MPMTIREAEKLLKEAGFREVKGGKGSHRKFVKENFPRPVILTSHSKELSKRVEESVRKAVGL

Nucleotide

• Length: 189 bp

>T152910 NZ_CP066569:c41771-41499 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACATATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10667.35 Da
• Isoelectric Point: 8.8302

>AT152910 WP_154731699.1 NZ_CP050485:341576-341845 [Enterococcus gallinarum]
VKVNYDEVYQVELIKELSARVYGRLLNMILEAGYDKTDRSIFECLLLQQFKEHKRSNLFDKNLKELEELKAYWHSMNQLT
KDLSKKRVA

Nucleotide

• Length: 270 bp

>AT152910 NZ_CP066569:c42034-41771 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTTGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA