Detailed information of TA system TA152907

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 3369177..3370524
• Replicon: chromosome
• Accession: NZ_CP050475
• Organism: Vibrio campbellii strain LJC012

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: HB763_RS15655
• Protein ID: WP_255984946.1
• Coordinates: 3369583..3370524 (+)
• Length: 314 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: HB763_RS15650
• Protein ID: WP_225490059.1
• Coordinates: 3369177..3369581 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB763_RS15635 (HB763_15655)	3366841..3367293	-	453	WP_021018079.1	hypothetical protein	-
HB763_RS15640 (HB763_15660)	3367873..3368115	+	243	WP_061007694.1	helix-turn-helix domain-containing protein	-
HB763_RS15645 (HB763_15665)	3368395..3368988	+	594	WP_167425793.1	tyrosine-type recombinase/integrase	-
HB763_RS15650 (HB763_15670)	3369177..3369581	+	405	WP_225490059.1	DUF6088 family protein	Antitoxin
HB763_RS15655 (HB763_15675)	3369583..3370524	+	942	WP_255984946.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HB763_RS15660 (HB763_15680)	3370544..3372061	+	1518	WP_255985801.1	type I restriction-modification system subunit M	-
HB763_RS15665 (HB763_15685)	3372051..3373208	+	1158	WP_255984947.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3305990..3386384	80394

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (37-300)

Antitoxin

• Protein of unknown function DUF6088 (7-130)

Sequences

Toxin

Protein

• Length: 314 a.a.
• Molecular weight: 35931.51 Da
• Isoelectric Point: 5.6793

>T152907 WP_255984946.1 NZ_CP050475:3369583-3370524 [Vibrio campbellii]
MNTLKQQFLEVSDALELGNPAIIEKDYWVVALLAELAKVCPEHHQMVFSGGTALAKSNVKILRMSEDVDIKLIPNQAFDE
LSRARKKAARKACVNEIEQAITRSELFTVEERSVRDEYRYVEFELKYPQQFSQAPCLRPIIKLELIETIPLLDVEPRSIQ
SLVAELYQQPQEVRAFDCVSIHATLVEKIISMLRRTMSVKRNTDRSDDVALVRHIYDVHCITKLAMPELNGIVGIFKAVL
EEDIARFGNQHAEFVANPKHELQLGLKELEENAIFRQRFQEFVTPMVFNTEPHDFDTCFASFKRIAASLIEKI

Nucleotide

• Length: 942 bp

>T152907 NZ_CP066567:1577686-1577946 [Histophilus somni]
ATGTACACTTTACGGTATAGTGATAAGGCGTTGAAGCAATTATGCAAGCTTGATAAAGGCACACAAAAGTTGATTTTGAC
TTGGATAGCAAATAACTTAGAGAACTGCGAAAATCCAAGAATAAAAGGCAAAGGACTTACTAGGAATCGAAGTGGAGAAT
GGCGGTATAGAGTAGGCGACTATCGGATTATTTGTGATATACGAGATAGTGAATTGATAATACTTGCCTTGTCTATTGGA
CACAGGAAAAATATTTATTAG

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 15214.55 Da
• Isoelectric Point: 10.5319

>AT152907 WP_225490059.1 NZ_CP050475:3369177-3369581 [Vibrio campbellii]
MTAVDRIYQKIKRSRRYVFERKDFDGFASYDQIGRALRQLVQQGELMKLGYGLYTKARINSLTGKPMPTNPGGTDALMRE
ILKMKGVDFEMDSLSLQSLSGSSTQIPSSIQYSWDPKQFNRKLVVGSRVLNLPS

Nucleotide

• Length: 405 bp

>AT152907 NZ_CP066567:1577465-1577686 [Histophilus somni]
ATGGCTATTTCAGTAAGACTAAACGCTCAAGACGAGCAATTATTTAAGTCCTATGCAAAAACAAATAATATTACGCTATC
CGAACTGTTCAGGAATGCCGTTTTTGAAAAAATCGAAGATGAATATGACCTTGCAGTATATCGTGAGTCTTTGGAAGACT
ACAACAAAACCCCAATGAGTTATTCTCACGCAGAGGTATGCAAGATGTTAGGAATTGAGTGA