Detailed information of TA system TA152906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 830250..831597
• Replicon: chromosome
• Accession: NZ_CP050475
• Organism: Vibrio campbellii strain LJC012

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: HB763_RS03905
• Protein ID: WP_255985428.1
• Coordinates: 830656..831597 (+)
• Length: 314 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: HB763_RS03900
• Protein ID: WP_061007692.1
• Coordinates: 830250..830654 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB763_RS03870 (HB763_03880)	825329..825853	+	525	WP_255985424.1	hypothetical protein	-
HB763_RS03875 (HB763_03885)	826068..826379	-	312	WP_137032986.1	helix-turn-helix transcriptional regulator	-
HB763_RS03880 (HB763_03890)	826483..827013	+	531	WP_255985750.1	hypothetical protein	-
HB763_RS03885 (HB763_03895)	827007..828386	+	1380	WP_255985425.1	DEAD/DEAH box helicase family protein	-
HB763_RS03890 (HB763_03900)	828489..828776	+	288	WP_255985426.1	hypothetical protein	-
HB763_RS03895 (HB763_03905)	829468..830061	+	594	WP_255985427.1	tyrosine-type recombinase/integrase	-
HB763_RS03900 (HB763_03910)	830250..830654	+	405	WP_061007692.1	DUF6088 family protein	Antitoxin
HB763_RS03905 (HB763_03915)	830656..831597	+	942	WP_255985428.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HB763_RS03910 (HB763_03920)	831617..833149	+	1533	WP_255985751.1	type I restriction-modification system subunit M	-
HB763_RS03915 (HB763_03925)	833139..834383	+	1245	WP_255985429.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	820453..844594	24141

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (32-300)

Antitoxin

• Protein of unknown function DUF6088 (7-130)

Sequences

Toxin

Protein

• Length: 314 a.a.
• Molecular weight: 35764.28 Da
• Isoelectric Point: 5.6989

>T152906 WP_255985428.1 NZ_CP050475:830656-831597 [Vibrio campbellii]
MNTLKQQFLEVSDALELGNPAIIEKDYWVVTLLAELAKVSPEHHQMVFSGGTALAKSNVKILRMSEDVDIKLIPNPAFDE
LSRAKKKAARKACVNEIEQAITQSERFTVETRSVRDEYRYVEFELKYPQQFSQAPCLRPIIKLELIETIPLLDVESRSIQ
SLVAELYQQPHEVSAFDCVSVYATLVEKVISMLRRTMSVKRNTERSDDVALVRHIYDVHCITKLSMPVIASIGGLFKTVL
EEDIARFGNQHAEFVANPKQELLLGLKELEENPIFRQRFQDFVTPMVFNTEPHDFDTCFASFKRIAASLIEKI

Nucleotide

• Length: 942 bp

>T152906 NZ_CP066567:437437-437904 [Histophilus somni]
ATGTATTCAGCACCTGAGCTATTAACACATCATCACCATTTAGGTGCATTTAATTGTGGTGAAGAGTCATTAAATATTTG
GCTTAAACGTCATGCACTTAAAAACCGGCAAAACCGAGCAAGTAGAACATTTGTGATCTGCAATGAAAATGTCGTTGTTG
GCTTCTATGCACTAGCGGCAGGTTCAGTGACGCAGCGGTTTGTATCCGGAGCATTAAGACGTAATATGCCTGAGCCTATT
CCTGTTGTTGTTTTAGGAAGATTAGCTATAGATATAAAACATCAAGGAAAAAAATTAGGTGCTGCATTACTTAAAGATGT
TGTACTACGAGCAAGAGCTGTGTCAGAACAAGTTGGAGTAAGAGCTTTGCTCGTACACGCTTTAAATGATAAAGCAAAAC
AATTCTATCTCAATTATGGTTTTCAACCTTCGCCAATTGATGATATGTTATTGATGTTGAAGTTGTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 15154.52 Da
• Isoelectric Point: 10.4983

>AT152906 WP_061007692.1 NZ_CP050475:830250-830654 [Vibrio campbellii]
MTAVDRICQKIKRSRRYVFERKDFDGFASYDQIGRALRQLVQQGELMKLGYGLYTKARINSLTGKPMPTNPGGTDALMRE
ILKMKGVDFEMDSLSLQSLSGSSTQIPSSIQYSWDPKQFNRKLVVGSRVLNLPS

Nucleotide

• Length: 405 bp

>AT152906 NZ_CP066567:437172-437435 [Histophilus somni]
ATGCGTACCGCTGCAATTAACCTACGAGTCCAGCCAAAGCAACGTGACTTAATTGATTATGCCGCTTCATTACTCGGAAA
AACACGTTCTGATTTTATGCTTGATGTTGCTTGCACTTATGCACAAAACGTGATTTTAGACAGAACAGTTTTTCAGCTTG
ATGAAGGAAAATTCAATCATTTTATTGAAGTACTTGAACAGCCTAATTTACCTAATGCCGGGTTGGAAAAATTAATGGCA
ACTCATTCACCTTGGGAATCATAA