Detailed information of TA system TA152903

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/YefM(antitoxin)
• Location: 76794..77356
• Replicon: plasmid unnamed1
• Accession: NZ_CP050469
• Organism: Vibrio campbellii strain LJC014

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HB761_RS25015
• Protein ID: WP_255944439.1
• Coordinates: 77054..77356 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A7N8Z2
• Locus tag: HB761_RS25010
• Protein ID: WP_005534943.1
• Coordinates: 76794..77054 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB761_RS24985 (HB761_24870)	71935..72189	-	255	Protein_72	transposase	-
HB761_RS24990 (HB761_24875)	72302..74194	-	1893	WP_255944438.1	methyl-accepting chemotaxis protein	-
HB761_RS24995	74504..75265	-	762	Protein_74	IS66 family transposase	-
HB761_RS25000 (HB761_24890)	75271..75744	-	474	Protein_75	IS6 family transposase	-
HB761_RS25005 (HB761_24895)	76046..76584	-	539	Protein_76	recombinase family protein	-
HB761_RS25010 (HB761_24900)	76794..77054	+	261	WP_005534943.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HB761_RS25015 (HB761_24905)	77054..77356	+	303	WP_255944439.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HB761_RS25020 (HB761_24910)	77331..77954	-	624	WP_255944440.1	recombinase family protein	-
HB761_RS25025 (HB761_24915)	78561..79637	-	1077	WP_255944441.1	replication initiation protein	-
HB761_RS25030 (HB761_24920)	80577..81152	+	576	WP_255944442.1	hypothetical protein	-
HB761_RS25035	81161..81298	+	138	WP_255944443.1	hypothetical protein	-
HB761_RS25040 (HB761_24925)	81288..82037	+	750	WP_228176155.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..83399	83399

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-57)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11548.39 Da
• Isoelectric Point: 9.3163

>T152903 WP_255944439.1 NZ_CP050469:77054-77356 [Vibrio campbellii]
MTQYKLSPAAQTDLIDIRRYTLENWGGAQWTNYFGELKQSMALLASNELIGIDMPELGTGYCRFPLKYHVIYYIRKPDHI
VIAAVLGRNMSPAKHFQRQL

Nucleotide

• Length: 303 bp

>T152903 NZ_CP066566:437115-437582 [Histophilus somni]
ATGTATTCAGCACCTGAGCTATTAACACATCATCACCATTTAGGTGCATTTAATTGTGGTGAAGAGTCATTAAATATTTG
GCTTAAACGTCATGCACTTAAAAACCGGCAAAACCGAGCAAGTAGAACATTTGTGATCTGCAATGAAAATGTCGTTGTTG
GCTTCTATGCACTAGCGGCAGGTTCAGTGACGCAGCGGTTTGTATCCGGAGCATTAAGACGTAATATGCCTGAGCCTATT
CCTGTTGTTGTTTTAGGAAGATTAGCTATAGATATAAAACATCAAGGAAAAAAATTAGGTGCTGCATTACTTAAAGATGT
TGTACTACGAGCAAGAGCTGTGTCAGAACAAGTTGGAGTAAGAGCTTTGCTCGTACACGCTTTAAATGATAAAGCAAAAC
AATTCTATCTCAATTATGGTTTTCAACCTTCGCCAATTGATGATATGTTATTGATGTTGAAGTTGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9620.95 Da
• Isoelectric Point: 4.2703

>AT152903 WP_005534943.1 NZ_CP050469:76794-77054 [Vibrio campbellii]
MQSLTANTAKTKFGDLLMKVQREPVQISKNGSPVAVVMSCEEYEELEALKMAMVKSRFEQAERDIVNGDLVDGETFMNEL
DSGKFD

Nucleotide

• Length: 261 bp

>AT152903 NZ_CP066566:436850-437113 [Histophilus somni]
ATGCGTACCGCTGCAATTAACCTACGAGTCCAGCCAAAGCAACGTGACTTAATTGATTATGCCGCTTCATTACTCGGAAA
AACACGTTCTGATTTTATGCTTGATGTTGCTTGCACTTATGCACAAAACGTGATTTTAGACAGAACAGTTTTTCAGCTTG
ATGAAGGAAAATTCAATCATTTTATTGAAGTACTTGAACAGCCTAATTTACCTAATGCCGGGTTGGAAAAATTAATGGCA
ACTCATTCACCTTGGGAATCATAA

Structures

Antitoxin

• AlphaFold DB: A7N8Z2