Detailed information of TA system TA152902

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/YefM(antitoxin)
• Location: 7510..8072
• Replicon: plasmid unnamed1
• Accession: NZ_CP050469
• Organism: Vibrio campbellii strain LJC014

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HB761_RS24670
• Protein ID: WP_255944439.1
• Coordinates: 7770..8072 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A7N8Z2
• Locus tag: HB761_RS24665
• Protein ID: WP_005534943.1
• Coordinates: 7510..7770 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB761_RS24640 (HB761_24525)	2678..2907	-	230	Protein_3	transposase	-
HB761_RS24645 (HB761_24530)	3020..4912	-	1893	WP_255944438.1	methyl-accepting chemotaxis protein	-
HB761_RS24650	5222..5982	-	761	Protein_5	IS66 family transposase	-
HB761_RS24655 (HB761_24545)	5988..6461	-	474	Protein_6	IS6 family transposase	-
HB761_RS24660 (HB761_24550)	6750..7300	-	551	Protein_7	recombinase family protein	-
HB761_RS24665 (HB761_24555)	7510..7770	+	261	WP_005534943.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HB761_RS24670 (HB761_24560)	7770..8072	+	303	WP_255944439.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HB761_RS24675 (HB761_24565)	8047..8670	-	624	WP_255944440.1	recombinase family protein	-
HB761_RS24680 (HB761_24570)	9277..10353	-	1077	WP_255944441.1	replication initiation protein	-
HB761_RS24685 (HB761_24575)	11293..12015	+	723	WP_038868832.1	hypothetical protein	-
HB761_RS24690 (HB761_24580)	12005..12754	+	750	WP_228176155.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..83399	83399

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-57)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11548.39 Da
• Isoelectric Point: 9.3163

>T152902 WP_255944439.1 NZ_CP050469:7770-8072 [Vibrio campbellii]
MTQYKLSPAAQTDLIDIRRYTLENWGGAQWTNYFGELKQSMALLASNELIGIDMPELGTGYCRFPLKYHVIYYIRKPDHI
VIAAVLGRNMSPAKHFQRQL

Nucleotide

• Length: 303 bp

>T152902 NZ_CP066566:436476-436712 [Histophilus somni]
TTGAATCTCTATTTACAAAAACAGGTTTCACAAGATATCAAAAGGCGTATTGCTCCTTGCTTTACTGTCATTGATGAAAA
TAAACGTATTTTAGGCTACTATACTTTAGCCTCAACAAGCATTCCTCTTGTCTCTCTCCCTGAGAACCTTAAGAAAAAAT
TACCCCGTTATCCTAGTGTTCCGGCGGTTTTACTTGGACGCTTAGCCGTTGACAAGCAAGTCTCAATATTCATTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9620.95 Da
• Isoelectric Point: 4.2703

>AT152902 WP_005534943.1 NZ_CP050469:7510-7770 [Vibrio campbellii]
MQSLTANTAKTKFGDLLMKVQREPVQISKNGSPVAVVMSCEEYEELEALKMAMVKSRFEQAERDIVNGDLVDGETFMNEL
DSGKFD

Nucleotide

• Length: 261 bp

>AT152902 NZ_CP066566:436850-437113 [Histophilus somni]
ATGCGTACCGCTGCAATTAACCTACGAGTCCAGCCAAAGCAACGTGACTTAATTGATTATGCCGCTTCATTACTCGGAAA
AACACGTTCTGATTTTATGCTTGATGTTGCTTGCACTTATGCACAAAACGTGATTTTAGACAGAACAGTTTTTCAGCTTG
ATGAAGGAAAATTCAATCATTTTATTGAAGTACTTGAACAGCCTAATTTACCTAATGCCGGGTTGGAAAAATTAATGGCA
ACTCATTCACCTTGGGAATCATAA

Structures

Antitoxin

• AlphaFold DB: A7N8Z2