Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1471745..1472495 Replicon chromosome
Accession NZ_CP050459
Organism Mammaliicoccus vitulinus strain Ani_LG-101

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag G7A42_RS07345 Protein ID WP_233709559.1
Coordinates 1472349..1472495 (+) Length 49 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag G7A42_RS07340 Protein ID WP_016913145.1
Coordinates 1471745..1472344 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7A42_RS07315 (G7A42_07310) 1467605..1468366 + 762 WP_103323121.1 acetylglutamate kinase -
G7A42_RS07320 (G7A42_07315) 1468688..1469815 + 1128 WP_209354519.1 tRNA epoxyqueuosine(34) reductase QueG -
G7A42_RS07325 (G7A42_07320) 1469819..1470292 + 474 WP_103323120.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
G7A42_RS07330 (G7A42_07325) 1470322..1470459 - 138 WP_016913147.1 hypothetical protein -
G7A42_RS07335 (G7A42_07330) 1470546..1471697 + 1152 WP_209354520.1 N-acetylglucosamine-6-phosphate deacetylase -
G7A42_RS07340 (G7A42_07335) 1471745..1472344 + 600 WP_016913145.1 hypothetical protein Antitoxin
G7A42_RS07345 (G7A42_07340) 1472349..1472495 + 147 WP_233709559.1 SAS053 family protein Toxin
G7A42_RS07350 (G7A42_07345) 1473340..1474728 + 1389 WP_103323118.1 class II fumarate hydratase -
G7A42_RS07355 (G7A42_07350) 1474817..1476343 + 1527 WP_103323117.1 exopolyphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(134-195)


Sequences

Toxin        


Download         Length: 49 a.a.        Molecular weight: 5721.14 Da        Isoelectric Point: 3.8810

>T152899 WP_233709559.1 NZ_CP050459:1472349-1472495 [Mammaliicoccus vitulinus]
VKLLNKHPEEENEMVQDLDDVKELGKEMEQISEQNDEAYEEKKEEQDS

Download         Length: 147 bp

>T152899 NZ_CP066565:c485562-485302 [Histophilus somni]
ATGTACACTTTACGGTATAGTGATAAGGCGTTGAAGCAACTATGCAAGCTTGATAAAGGCACACAAAAGTTGATTTTGAC
TTGGATAGCAAATAACTTAGAGAACTGCGAAAATCCAAGAATAAAAGGCAAAGGACTTACTGGGAATCGAAGTGGAGAAT
GGCGGTATAGAGTAGGCGACTATCGGATTATTTGTGATATACGAGATAGTGAATTGATAATACTTGCCTTGTCTATTGGA
CACAGGAAAAATATTTATTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22350.23 Da        Isoelectric Point: 4.9814

>AT152899 WP_016913145.1 NZ_CP050459:1471745-1472344 [Mammaliicoccus vitulinus]
MALNFKVFETKDIAARYAADVVRKQFNSDSTSVVGIHLDAENTSFFDELLDDVKKNPVNFSQIHVLDFDGKEDYYTELGV
PKKQVLKTDVGSDVESFIKDKVNTDKKKNKLMLDVITLTEDSRTGLDYNQAIHPAREVIVLVTGKEKAKAVSQLYEEPAN
GSVESAKLKQHRMVTVLLDNEAAQGLPEDVRSYFSIQFS

Download         Length: 600 bp

>AT152899 NZ_CP066565:c485783-485562 [Histophilus somni]
ATGGCTATTTCAATAAGATTAAACGCTCAAGACGAGCAATTATTTAAGTCCTATGCAAAAACAAATAATATTACGCTATC
CGAACTGTTCAGGAATGCCGTTTTTGAAAAAATCGAAGATGAATATGACCTTGCAGTATATCGTGAGTCTTTGGAAGAAT
ACAACAAAACCCCAATGAGTTATTCTCACGCAGAGGTATGCAAGATGTTAGGAATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References