Detailed information of TA system TA152899

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1471745..1472495
• Replicon: chromosome
• Accession: NZ_CP050459
• Organism: Mammaliicoccus vitulinus strain Ani_LG-101

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: G7A42_RS07345
• Protein ID: WP_233709559.1
• Coordinates: 1472349..1472495 (+)
• Length: 49 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: G7A42_RS07340
• Protein ID: WP_016913145.1
• Coordinates: 1471745..1472344 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7A42_RS07315 (G7A42_07310)	1467605..1468366	+	762	WP_103323121.1	acetylglutamate kinase	-
G7A42_RS07320 (G7A42_07315)	1468688..1469815	+	1128	WP_209354519.1	tRNA epoxyqueuosine(34) reductase QueG	-
G7A42_RS07325 (G7A42_07320)	1469819..1470292	+	474	WP_103323120.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
G7A42_RS07330 (G7A42_07325)	1470322..1470459	-	138	WP_016913147.1	hypothetical protein	-
G7A42_RS07335 (G7A42_07330)	1470546..1471697	+	1152	WP_209354520.1	N-acetylglucosamine-6-phosphate deacetylase	-
G7A42_RS07340 (G7A42_07335)	1471745..1472344	+	600	WP_016913145.1	hypothetical protein	Antitoxin
G7A42_RS07345 (G7A42_07340)	1472349..1472495	+	147	WP_233709559.1	SAS053 family protein	Toxin
G7A42_RS07350 (G7A42_07345)	1473340..1474728	+	1389	WP_103323118.1	class II fumarate hydratase	-
G7A42_RS07355 (G7A42_07350)	1474817..1476343	+	1527	WP_103323117.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (134-195)

Sequences

Toxin

Protein

• Length: 49 a.a.
• Molecular weight: 5721.14 Da
• Isoelectric Point: 3.8810

>T152899 WP_233709559.1 NZ_CP050459:1472349-1472495 [Mammaliicoccus vitulinus]
VKLLNKHPEEENEMVQDLDDVKELGKEMEQISEQNDEAYEEKKEEQDS

Nucleotide

• Length: 147 bp

>T152899 NZ_CP066565:c485562-485302 [Histophilus somni]
ATGTACACTTTACGGTATAGTGATAAGGCGTTGAAGCAACTATGCAAGCTTGATAAAGGCACACAAAAGTTGATTTTGAC
TTGGATAGCAAATAACTTAGAGAACTGCGAAAATCCAAGAATAAAAGGCAAAGGACTTACTGGGAATCGAAGTGGAGAAT
GGCGGTATAGAGTAGGCGACTATCGGATTATTTGTGATATACGAGATAGTGAATTGATAATACTTGCCTTGTCTATTGGA
CACAGGAAAAATATTTATTAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22350.23 Da
• Isoelectric Point: 4.9814

>AT152899 WP_016913145.1 NZ_CP050459:1471745-1472344 [Mammaliicoccus vitulinus]
MALNFKVFETKDIAARYAADVVRKQFNSDSTSVVGIHLDAENTSFFDELLDDVKKNPVNFSQIHVLDFDGKEDYYTELGV
PKKQVLKTDVGSDVESFIKDKVNTDKKKNKLMLDVITLTEDSRTGLDYNQAIHPAREVIVLVTGKEKAKAVSQLYEEPAN
GSVESAKLKQHRMVTVLLDNEAAQGLPEDVRSYFSIQFS

Nucleotide

• Length: 600 bp

>AT152899 NZ_CP066565:c485783-485562 [Histophilus somni]
ATGGCTATTTCAATAAGATTAAACGCTCAAGACGAGCAATTATTTAAGTCCTATGCAAAAACAAATAATATTACGCTATC
CGAACTGTTCAGGAATGCCGTTTTTGAAAAAATCGAAGATGAATATGACCTTGCAGTATATCGTGAGTCTTTGGAAGAAT
ACAACAAAACCCCAATGAGTTATTCTCACGCAGAGGTATGCAAGATGTTAGGAATTGAGTGA