152898

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1299215..1299754 Replicon chromosome
Accession NZ_CP050459
Organism Mammaliicoccus vitulinus strain Ani_LG-101

Toxin (Protein)


Gene name mazF Uniprot ID A0A2T4PTI0
Locus tag G7A42_RS06355 Protein ID WP_016910942.1
Coordinates 1299383..1299754 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PTG6
Locus tag G7A42_RS06350 Protein ID WP_016910943.1
Coordinates 1299215..1299382 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7A42_RS06325 (G7A42_06320) 1295102..1295581 + 480 WP_016910948.1 PH domain-containing protein -
G7A42_RS06330 (G7A42_06325) 1295571..1297082 + 1512 WP_209355065.1 PH domain-containing protein -
G7A42_RS06335 (G7A42_06330) 1297072..1297554 + 483 WP_016910946.1 PH domain-containing protein -
G7A42_RS06340 (G7A42_06335) 1297566..1297934 + 369 WP_016910945.1 holo-ACP synthase -
G7A42_RS06345 (G7A42_06340) 1297982..1299130 + 1149 WP_016910944.1 alanine racemase -
G7A42_RS06350 (G7A42_06345) 1299215..1299382 + 168 WP_016910943.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
G7A42_RS06355 (G7A42_06350) 1299383..1299754 + 372 WP_016910942.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G7A42_RS06360 (G7A42_06355) 1299857..1300861 + 1005 WP_016910941.1 PP2C family protein-serine/threonine phosphatase -
G7A42_RS06365 (G7A42_06360) 1300935..1301258 + 324 WP_016910940.1 anti-sigma factor antagonist -
G7A42_RS06370 (G7A42_06365) 1301263..1301739 + 477 WP_016910939.1 anti-sigma B factor RsbW -
G7A42_RS06375 (G7A42_06370) 1301714..1302484 + 771 WP_016910938.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13611.75 Da        Isoelectric Point: 9.9193

>T152898 WP_016910942.1 NZ_CP050459:1299383-1299754 [Mammaliicoccus vitulinus]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDTAIAISLNLTLQQKFDALGNT

Download         Length: 372 bp

>T152898 NZ_CP066564:c1724291-1723824 [Histophilus somni]
ATGTATTCAGCACCTGAGCTATTAACACATCATCACCATTTAGGTGCATTTAATTGTGGTGAAGAGTCATTAAATATTTG
GCTTAAACGTCATGCACTTAGAAACCGGCAAAACCGAGCAAGTAGAACATTTGTGATCTGCAATGAAAATGTCGTTGTTG
GCTTCTATGCACTAGCGGCAGGTTCAGTGACGCATCGGTTTGTATCCGGAGCATTAAGACGTAATATGCCTGAGCCTATT
CCTGTTGTTGTTTTAGGAAGATTAGCTATAGATATAAAACATCAAGGAAAAAAATTAGGTGCTGCATTACTTAAAGATGT
TGTACTACGAGCAAGAGCTGTGTCAGAACAAGTTGGAGTAAGAGCTTTGCTCGTACACGCTTTAAATGATAAAGCAAAAC
AATTCTATCTCAATTATGGTTTTCAACCTTCACCAATTGATGATATGTTATTGATGTTGAAGTTATAA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6120.58 Da        Isoelectric Point: 4.0121

>AT152898 WP_016910943.1 NZ_CP050459:1299215-1299382 [Mammaliicoccus vitulinus]
MTSLTQNRTQSIEQTLKEGYRSMADLNLSLASEAYYSECEACDSNESHLASQQGE

Download         Length: 168 bp

>AT152898 NZ_CP066564:c1724556-1724293 [Histophilus somni]
ATGCGTACCGCTGCAATTAACCTACGAGTCCAGCCAAAGCAACGTGACTTAATTGATTATGCCGCTTCATTACTCGGAAA
AACACGTTCTGATTTTATGCTTGATGTTGCTTGCACTTATGCACAAAACGTGATTTTAGACAGAACAGTTTTTCAGCTTG
ATGAAGGAAAATTCAATCATTTTATTGAAGTACTTGAACAGCCTAATTTACCTAATGCCGGGTTGGAAAAATTAATGGCA
ACTCATTCACCTTGGGAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4PTI0

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PTG6

References