152897

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 715882..716468 Replicon chromosome
Accession NZ_CP050459
Organism Mammaliicoccus vitulinus strain Ani_LG-101

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag G7A42_RS03485 Protein ID WP_209354930.1
Coordinates 716136..716468 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag G7A42_RS03480 Protein ID WP_103322578.1
Coordinates 715882..716142 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7A42_RS03460 (G7A42_03460) 711818..713167 + 1350 WP_209354926.1 2-hydroxycarboxylate transporter family protein -
G7A42_RS03465 (G7A42_03465) 713199..714380 + 1182 WP_209354927.1 NADP-dependent malic enzyme -
G7A42_RS03470 (G7A42_03470) 714470..715189 - 720 WP_209354928.1 LysR family transcriptional regulator -
G7A42_RS03475 (G7A42_03475) 715287..715820 + 534 WP_209354929.1 DUF4865 family protein -
G7A42_RS03480 (G7A42_03480) 715882..716142 + 261 WP_103322578.1 AbrB family transcriptional regulator Antitoxin
G7A42_RS03485 (G7A42_03485) 716136..716468 + 333 WP_209354930.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G7A42_RS03490 (G7A42_03490) 716719..717327 + 609 WP_209354931.1 hypothetical protein -
G7A42_RS03495 (G7A42_03495) 717381..718364 - 984 WP_209354932.1 iron ABC transporter permease -
G7A42_RS03500 (G7A42_03500) 718361..719359 - 999 WP_107536572.1 iron ABC transporter permease -
G7A42_RS03505 (G7A42_03505) 719349..720278 - 930 WP_107536573.1 iron-siderophore ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12559.55 Da        Isoelectric Point: 7.1323

>T152897 WP_209354930.1 NZ_CP050459:716136-716468 [Mammaliicoccus vitulinus]
MVIQYDIIKLNLNPVQGNEKGNYRPCLVVNITEFTKQSDFAWVIPITSRKQSRYPTDVIVETEKGLINGVVDCAHIRTVD
LYTRSHQKVDVLKANKIEEVKDILTGIMDL

Download         Length: 333 bp

>T152897 NZ_CP066564:c1359494-1359189 [Histophilus somni]
ATGTCTGGTAAACAATTAAAGGTCAGTTACTCTAAACAATTTGCTAGAGATTTGACTGATTTGGCAAAACGTTACCCAAA
TGTGCTAGTAGGAACGAAATATATTACAGCAATGCACTGCTTGTTAAACCGCTTGCCATTGCCTGAAAGCTATCAAGATC
ACACATTAGTTGGAGAATGGAAAGGTTATCGAGATTGCCATATTCAAGGGGATTTGGTGCTGATTTACCAATACGTTATA
CACGATGAATTTGATGCGTTGAAATTTTCTCGTTTAAATACCTACTCGCAAACAGCTTCAAAATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9950.21 Da        Isoelectric Point: 5.2300

>AT152897 WP_103322578.1 NZ_CP050459:715882-716142 [Mammaliicoccus vitulinus]
MSEPTNKAYAKVYKSGNGQVISIKKDMLEKAGFKIGDELVMNVKGNQIVLEKPNTFKDRWRKFIEDGGEYERGEYDWGES
VGREEW

Download         Length: 261 bp

>AT152897 NZ_CP066564:c1359788-1359498 [Histophilus somni]
ATGGCACTTACAAATGCGTCTATCAGCTTTAGAACAGTTGAGCAAACTAAATCCGAAGCCTATCAGGTCATTGAACAATA
TGGTCTTACACCATCACAAGTATTTAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCTTAGCAGCTATGGACGAATTAGATAGCGGTAATGCAGAGAGCTTTTTTATTGAAGCT
GGAGAAAATTATTCTGTCGAAGAGTTTACAAAACGCATTCTTAACGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References