152896

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 492497..493152 Replicon chromosome
Accession NZ_CP050453
Organism Microbacterium sp. Se63.02b

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G4G29_RS02475 Protein ID WP_183151734.1
Coordinates 492757..493152 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G4G29_RS02470 Protein ID WP_183151733.1
Coordinates 492497..492760 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4G29_RS02455 487693..489271 + 1579 Protein_489 5-oxoprolinase/urea amidolyase family protein -
G4G29_RS02460 489268..490980 + 1713 WP_183151731.1 ATP-grasp domain-containing protein -
G4G29_RS02465 491056..492384 - 1329 WP_183151732.1 nitrate reductase -
G4G29_RS02470 492497..492760 + 264 WP_183151733.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G4G29_RS02475 492757..493152 + 396 WP_183151734.1 type II toxin-antitoxin system VapC family toxin Toxin
G4G29_RS02480 493157..494035 - 879 WP_183151735.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
G4G29_RS02485 494113..494738 + 626 Protein_495 PadR family transcriptional regulator -
G4G29_RS02490 494735..496288 + 1554 WP_183151736.1 DHA2 family efflux MFS transporter permease subunit -
G4G29_RS02495 496342..496882 + 541 Protein_497 GNAT family N-acetyltransferase -
G4G29_RS02500 496901..497779 - 879 WP_202045520.1 ROK family protein -
G4G29_RS20475 497737..498117 - 381 WP_202045523.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-86)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14084.03 Da        Isoelectric Point: 4.3953

>T152896 WP_183151734.1 NZ_CP050453:492757-493152 [Microbacterium sp. Se63.02b]
VIVDSSALVAILMEEAEAAEFSFRLATEDPMISAASLTECMIVLHGKAGEGMVRELDVLLRSAAVAVLPVDEAQARLAGN
AYARYGRGSGSPARLNYGDCFSYALAITRDEPLLFKGDDFVHTDVRRMESA

Download         Length: 396 bp

>T152896 NZ_CP066564:1171977-1172249 [Histophilus somni]
ATGGCTAAACGCAAATTTGATATGGCAAAATCTTTTAAACGTGATTTGAGAAAACATTACTTGGCTTTAGTCGGCGAAGC
ATGGGCAGAGATTTCAAACTGTCTTTTGAATGACTTGCCAATTCCTGAAAAGTATCAAGATCACCCGCTTAAAGGCGATA
AATCAGGCTTTCGAGACTGCCATGTCAAACCGGATTTAGTGTTGATATACAAAATCGTTGATGATGTTGTGGAGTTACAT
TACCTTGATAGCCATAGCGAAATTTTTGGCTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9890.16 Da        Isoelectric Point: 5.2473

>AT152896 WP_183151733.1 NZ_CP050453:492497-492760 [Microbacterium sp. Se63.02b]
MSLNIKNETTHELVRRLAALTGQSQTGAVEDAVRRRLAELEQSREEEIERKRAAIDAVVARARLIPRTGRTTEEIMDELY
DEAGMPR

Download         Length: 264 bp

>AT152896 NZ_CP066564:1171691-1171984 [Histophilus somni]
ATGGATTATACAAATTTTAATATGCGACTTGATAACGACTTGCGTGGACGGGCTTATCCTATTTTGGAGCAGTATGGATT
GACGCCAAGTCAAGCGGTAAGAATGTTTTTTAATCAGATTGCACAAACCGGTAAAATACCCTTGTCGTTTGATTGGGCGG
AAAATCAAACTTTAACCCCAAAAGCAGCCGCACGGTTACGCCAAACTGAGCAGGAATTCGCCAATGGCGAATTTGAACGC
TTTTATAGCCTAGATGAACTCAATCAAGCGATAAAGGAGATCTCGCATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References