Detailed information of TA system TA152892

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 4792846..4793393
• Replicon: chromosome
• Accession: NZ_CP050447
• Organism: Serratia marcescens strain SER00094

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: A0A380ADA6
• Locus tag: HCG50_RS22725
• Protein ID: WP_025302144.1
• Coordinates: 4793085..4793393 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: HCG50_RS22720
• Protein ID: WP_025302143.1
• Coordinates: 4792846..4793082 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HCG50_RS22705	4789332..4790867	+	1536	WP_025302140.1	glutathione ABC transporter substrate-binding protein GsiB	-
HCG50_RS22710	4790920..4791840	+	921	WP_025302141.1	glutathione ABC transporter permease GsiC	-
HCG50_RS22715	4791850..4792758	+	909	WP_169540348.1	glutathione ABC transporter permease GsiD	-
HCG50_RS22720	4792846..4793082	+	237	WP_025302143.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
HCG50_RS22725	4793085..4793393	+	309	WP_025302144.1	CcdB family protein	Toxin
HCG50_RS22730	4793433..4794275	-	843	WP_015377214.1	S-formylglutathione hydrolase	-
HCG50_RS22735	4794290..4795414	-	1125	WP_016928454.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	-
HCG50_RS22740	4795444..4796364	-	921	WP_025302145.1	LysR family transcriptional regulator	-
HCG50_RS22745	4796470..4797627	+	1158	WP_043142422.1	YbfB/YjiJ family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (8-78)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11504.32 Da
• Isoelectric Point: 5.0196

>T152892 WP_025302144.1 NZ_CP050447:4793085-4793393 [Serratia marcescens]
MQFTVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGKA
VGNVNEHRNQIKAAIDFLIDGF

Nucleotide

• Length: 309 bp

>T152892 NZ_CP066563:435897-436133 [Histophilus somni]
TTGAATCTCTATTTACAAAAACAGGTTTCACAAGATATCAAAAGGCGTATTGCTCCTTGCTTTACTGTCATTGATGAAAA
TAAACGTATTTTAGGCTACTATACTTTAGCCTCAACAAGCATTCCTCTTGTCTCTCTCCCTGAGAACCTTAAGAAAAAAT
TACCCCGTTATCCTAGTGTTCCGGCGGTTTTACTTGGACGCTTAGCCGTTGACAAGCAAGTCTCAATATTCATTTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8967.04 Da
• Isoelectric Point: 5.0807

>AT152892 WP_025302143.1 NZ_CP050447:4792846-4793082 [Serratia marcescens]
MANSNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Nucleotide

• Length: 237 bp

>AT152892 NZ_CP066563:436271-436534 [Histophilus somni]
ATGCGTACCGCTGCAATTAACCTACGAGTCCAGCCAAAGCAACGTGACTTAATTGATTATGCCGCTTCATTACTCGGAAA
AACACGTTCTGATTTTATGCTTGATGTTGCTTGCACTTATGCACAAAACGTGATTTTAGACAGAACAGTTTTTCAGCTTG
ATGAAGGAAAATTCAATCATTTTATTGAAGTACTTGAACAGCCTAATTTACCTAATGCCGGGTTGGAAAAATTAATGGCA
ACTCATTCACCTTGGGAATCATAA

Structures

Toxin

• AlphaFold DB: A0A380ADA6