Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4327337..4327959 Replicon chromosome
Accession NZ_CP050447
Organism Serratia marcescens strain SER00094

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag HCG50_RS20360 Protein ID WP_004940313.1
Coordinates 4327337..4327540 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag HCG50_RS20365 Protein ID WP_004940312.1
Coordinates 4327591..4327959 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCG50_RS20330 4323036..4323374 + 339 WP_004940327.1 P-II family nitrogen regulator -
HCG50_RS20335 4323411..4324697 + 1287 WP_038628958.1 ammonium transporter AmtB -
HCG50_RS20340 4324788..4325651 - 864 WP_016928847.1 acyl-CoA thioesterase II -
HCG50_RS20345 4325883..4326374 + 492 WP_025301777.1 YbaY family lipoprotein -
HCG50_RS20350 4326439..4326753 - 315 WP_025301778.1 MGMT family protein -
HCG50_RS20360 4327337..4327540 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
HCG50_RS20365 4327591..4327959 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
HCG50_RS20370 4328118..4328471 - 354 WP_025301779.1 hypothetical protein -
HCG50_RS20375 4328743..4328883 + 141 WP_167324227.1 hypothetical protein -
HCG50_RS20380 4328880..4329593 + 714 WP_167324878.1 ABC transporter ATP-binding protein -
HCG50_RS20385 4329590..4330447 + 858 WP_043135664.1 metal ABC transporter permease -
HCG50_RS20390 4330473..4331351 + 879 WP_049209312.1 metal ABC transporter substrate-binding protein -
HCG50_RS20395 4331460..4331600 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
HCG50_RS20400 4331613..4331867 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T152891 WP_004940313.1 NZ_CP050447:c4327540-4327337 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T152891 NZ_CP066562:1581082-1581342 [Histophilus somni]
ATGTACACTTTACGGTATAGTGATAAGGCGTTGAAGCAATTATGCAAGCTTGATAAAGGCACACAAAAGTTGATTTTGAC
TTGGATAGCAAATAACTTAGAGAACTGCGAAAATCCAAGAATAAAAGGCAAAGGACTTACTAGGAATCGAAGTGGAGAAT
GGCGGTATAGAGTAGGCGACTATCGGATTATTTGTGATATACGAGATAGTGAATTGATAATACTTGCCTTGTCTATTGGA
CACAGGAAAAATATTTATTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT152891 WP_004940312.1 NZ_CP050447:c4327959-4327591 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT152891 NZ_CP066562:1580861-1581082 [Histophilus somni]
ATGGCTATTTCAGTAAGACTAAACGCTCAAGACGAGCAATTATTTAAGTCCTATGCAAAAACAAATAATATTACGCTATC
CGAACTGTTCAGGAATGCCGTTTTTGAAAAAATCGAAGATGAATATGACCTTGCAGTATATCGTGAGTCTTTGGAAGACT
ACAACAAAACCCCAATGAGTTATTCTCACGCAGAGGTATGCAAGATGTTAGGAATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References