Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3164426..3165027 Replicon chromosome
Accession NZ_CP050447
Organism Serratia marcescens strain SER00094

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4GSJ7
Locus tag HCG50_RS14880 Protein ID WP_025304766.1
Coordinates 3164426..3164806 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8B4GSF3
Locus tag HCG50_RS14885 Protein ID WP_025304767.1
Coordinates 3164806..3165027 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCG50_RS14855 3159673..3160953 + 1281 WP_043140737.1 DUF3748 domain-containing protein -
HCG50_RS14860 3160984..3161331 - 348 WP_016929593.1 YceK/YidQ family lipoprotein -
HCG50_RS14865 3161641..3162054 + 414 WP_004933919.1 heat shock chaperone IbpA -
HCG50_RS14870 3162161..3162589 + 429 WP_004933922.1 heat shock chaperone IbpB -
HCG50_RS14875 3162757..3164415 + 1659 WP_167324694.1 putative transporter -
HCG50_RS14880 3164426..3164806 - 381 WP_025304766.1 type II toxin-antitoxin system VapC family toxin Toxin
HCG50_RS14885 3164806..3165027 - 222 WP_025304767.1 ribbon-helix-helix domain-containing protein Antitoxin
HCG50_RS14890 3165102..3166352 - 1251 WP_049204660.1 valine--pyruvate transaminase -
HCG50_RS14895 3166488..3168551 - 2064 WP_167324695.1 alpha-amylase -
HCG50_RS14900 3168748..3168900 + 153 WP_162837931.1 hypothetical protein -
HCG50_RS14905 3168902..3169879 - 978 WP_049204664.1 glyoxylate/hydroxypyruvate reductase GhrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-100)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14241.66 Da        Isoelectric Point: 7.3173

>T152890 WP_025304766.1 NZ_CP050447:c3164806-3164426 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQARDVLVEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRMLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T152890 NZ_CP066562:440579-441046 [Histophilus somni]
ATGTATTCAGCACCTGAGCTATTAACACATCATCACCATTTAGGTGCATTTAATTGTGGTGAAGAGTCATTAAATATTTG
GCTTAAACGTCATGCACTTAAAAACCGGCAAAACCGAGCAAGTAGAACATTTGTGATCTGCAATGAAAATGTCGTTGTTG
GCTTCTATGCACTAGCGGCAGGTTCAGTGACGCAGCGGTTTGTATCCGGAGCATTAAGACGTAATATGCCTGAGCCTATT
CCTGTTGTTGTTTTAGGAAGATTAGCTATAGATATAAAACATCAAGGAAAAAAATTAGGTGCTGCATTACTTAAAGATGT
TGTACTACGAGCAAGAGCTGTGTCAGAACAAGTTGGAGTAAGAGCTTTGCTCGTACACGCTTTAAATGATAAAGCAAAAC
AATTCTATCTCAATTATGGTTTTCAACCTTCGCCAATTGATGATATGTTATTGATGTTGAAGTTGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8607.55 Da        Isoelectric Point: 4.4915

>AT152890 WP_025304767.1 NZ_CP050447:c3165027-3164806 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVEYENRQREEWE

Download         Length: 222 bp

>AT152890 NZ_CP066562:440314-440577 [Histophilus somni]
ATGCGTACCGCTGCAATTAACCTACGAGTCCAGCCAAAGCAACGTGACTTAATTGATTATGCCGCTTCATTACTCGGAAA
AACACGTTCTGATTTTATGCTTGATGTTGCTTGCACTTATGCACAAAACGTGATTTTAGACAGAACAGTTTTTCAGCTTG
ATGAAGGAAAATTCAATCATTTTATTGAAGTACTTGAACAGCCTAATTTACCTAATGCCGGGTTGGAAAAATTAATGGCA
ACTCATTCACCTTGGGAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GSJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GSF3

References