Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1791703..1792359 Replicon chromosome
Accession NZ_CP050447
Organism Serratia marcescens strain SER00094

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HCG50_RS08445 Protein ID WP_049204858.1
Coordinates 1791703..1792092 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag HCG50_RS08450 Protein ID WP_004941563.1
Coordinates 1792096..1792359 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCG50_RS08430 1788170..1789600 + 1431 WP_147824119.1 MFS transporter -
HCG50_RS08435 1789597..1790979 + 1383 WP_049204856.1 two-component system sensor histidine kinase BaeS -
HCG50_RS08440 1790979..1791695 + 717 WP_004941568.1 two-component system response regulator BaeR -
HCG50_RS08445 1791703..1792092 - 390 WP_049204858.1 type II toxin-antitoxin system VapC family toxin Toxin
HCG50_RS08450 1792096..1792359 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HCG50_RS08455 1792697..1793035 + 339 WP_016926703.1 YegP family protein -
HCG50_RS08460 1793214..1794566 + 1353 WP_025303865.1 tRNA 5-hydroxyuridine modification protein YegQ -
HCG50_RS08465 1794783..1795004 - 222 WP_141998673.1 hypothetical protein -
HCG50_RS08470 1795034..1795939 + 906 WP_043137977.1 lipid kinase YegS -
HCG50_RS08475 1796108..1797322 + 1215 WP_025303867.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14423.73 Da        Isoelectric Point: 9.0823

>T152886 WP_049204858.1 NZ_CP050447:c1792092-1791703 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMQKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDREAARCYGEM
RANMERKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T152886 NZ_CP066558:1700943-1701203 [Histophilus somni]
ATGTACACTTTACGGTATAGTGATAAGGCGTTGAAGCAACTATGCAAGCTTGATAAAGGCACACAAAAGTTGATTTTGAC
TTGGATAGCAAATAACTTAGAGAACTGCGAAAATCCAAGAATAAAAGGCAAAGGACTTACTGGGAATCGAAGTGGAGAAT
GGCGGTATAGAGTAGGCGACTATCGGATTATTTGTGATATACGAGATAGTGAATTGATAATACTTGCCTTGTCTATTGGA
CACAGGAAAAATATTTATTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT152886 WP_004941563.1 NZ_CP050447:c1792359-1792096 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT152886 NZ_CP066558:1700722-1700943 [Histophilus somni]
ATGGCTATTTCAATAAGATTAAACGCTCAAGACGAGCAATTATTTAAGTCCTATGCAAAAACAAATAATATTACGCTATC
CGAACTGTTCAGGAATGCCGTTTTTGAAAAAATCGAAGATGAATATGACCTTGCAGTATATCGTGAGTCTTTGGAAGAAT
ACAACAAAACCCCAATGAGTTATTCTCACGCAGAGGTATGCAAGATGTTAGGAATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References