Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1701960..1702522 Replicon chromosome
Accession NZ_CP050447
Organism Serratia marcescens strain SER00094

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag HCG50_RS08020 Protein ID WP_025303801.1
Coordinates 1701960..1702316 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag HCG50_RS08025 Protein ID WP_004936539.1
Coordinates 1702313..1702522 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCG50_RS08000 1697696..1698493 - 798 WP_025303797.1 energy transducer TonB -
HCG50_RS08005 1698596..1699435 - 840 WP_167325036.1 ChaN family lipoprotein -
HCG50_RS08010 1699613..1701022 + 1410 WP_025303799.1 S-methylmethionine permease -
HCG50_RS08015 1701012..1701950 + 939 WP_025303800.1 homocysteine S-methyltransferase -
HCG50_RS08020 1701960..1702316 - 357 WP_025303801.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HCG50_RS08025 1702313..1702522 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HCG50_RS08030 1702632..1704911 - 2280 WP_016926766.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
HCG50_RS08035 1705126..1705299 - 174 WP_049205380.1 hypothetical protein -
HCG50_RS08040 1705280..1705660 - 381 WP_049209349.1 DUF2570 family protein -
HCG50_RS08045 1705657..1706058 - 402 WP_025303803.1 M15 family metallopeptidase -
HCG50_RS08050 1706048..1706374 - 327 WP_004936551.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(27-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13163.93 Da        Isoelectric Point: 4.9139

>T152885 WP_025303801.1 NZ_CP050447:c1702316-1701960 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHGRQEGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRRLTE

Download         Length: 357 bp

>T152885 NZ_CP066558:826841-827146 [Histophilus somni]
ATGTCTGGTAAACAATTAAAGGTCAGTTACTCTAAACAATTTGCTAGAGATTTGACTGATTTGGCAAAACGTTACCCAAA
TGTGCTAGTAGGAACGAAATATATTACAGCAATGCACTGCTTGTTAAACCGCTTGCCATTGCCTGAAAGCTATCAAGATC
ACACATTAGTTGGAGAATGGAAAGGTTATCGAGATTGCCATATTCAAGGGGATTTGGTGCTGATTTACCAATACGTTATA
CACGATGAATTTGATGCGTTGAAATTTTCTCGTTTAAATACCTACTCGCAAACAGCTTCAAAATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT152885 WP_004936539.1 NZ_CP050447:c1702522-1702313 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT152885 NZ_CP066558:826547-826837 [Histophilus somni]
ATGGCACTTACAAATGCGTCTATCAGCTTTAGAACAGTTGAGCAAACTAAATCCGAAGCCTATCAGGTCATTGAACAATA
TGGTCTTACACCATCACAAGTATTTAATATGTTTTTGGTTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCTTAGCAGCTATGGACGAATTAGATAGCGGTAATGCAGAGAGCTTTTTTATTGAAGCT
GGAGAAAATTATTCTGTCGAAGAGTTTACAAAACGCATTCTTAACGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References