Detailed information of TA system TA152872

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 2743408..2743918
• Replicon: chromosome
• Accession: NZ_CP050432
• Organism: Acinetobacter baumannii strain PM194229

Toxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4Q4HKU6
• Locus tag: HB663_RS13190
• Protein ID: WP_000824257.1
• Coordinates: 2743655..2743918 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7S8XU62
• Locus tag: HB663_RS13185
• Protein ID: WP_001165438.1
• Coordinates: 2743408..2743671 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB663_RS13165	2738820..2739847	+	1028	Protein_2577	hypothetical protein	-
HB663_RS13170	2740543..2741766	+	1224	WP_000261481.1	inovirus-type Gp2 protein	-
HB663_RS13175	2741763..2742791	+	1029	WP_001101792.1	hypothetical protein	-
HB663_RS13180	2742788..2743054	+	267	WP_000570798.1	AlpA family phage regulatory protein	-
HB663_RS13185	2743408..2743671	+	264	WP_001165438.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HB663_RS13190	2743655..2743918	+	264	WP_000824257.1	Txe/YoeB family addiction module toxin	Toxin
HB663_RS13195	2744122..2745309	-	1188	WP_002036368.1	DUF4268 domain-containing protein	-
HB663_RS13200	2745409..2746617	-	1209	WP_025466770.1	integrase arm-type DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2721661..2743918	22257

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10337.91 Da
• Isoelectric Point: 9.0098

>T152872 WP_000824257.1 NZ_CP050432:2743655-2743918 [Acinetobacter baumannii]
MKRKTSFTPTAWEDYVYWQNQDKKTLKRINTLIKECLRTPFDGIGKPEPLLGDLAGLWSRRIDEKNRLVYEVTDVAITII
SCRYHYE

Nucleotide

• Length: 264 bp

>T152872 NZ_CP066552:c4113807-4113394 [Pectobacterium carotovorum]
GTGGCCCAGTGGCAATGTGATCTTCGCGTTTCCTGGCGTATGCAACTGCTGTCGTTGGTGGTGCATGGTCTATTAGTATT
ACTCATTCTGCTGGCACCGTGGCCGGACGGTTATGCATGGCTGTGGCTTTGTCTGGTCACGATGGTGATGTTCGGTTTTA
TCCGTAGCCAACGGAATATCAAATCCCGACAGGGGGAAATCGTTCTGCTCAGCGAAACGACCCTGAACTGGCGGCAGCAG
GAATGGCAAATCGTTAAGCGACCGTGGCTGCTGAAGAATGGCGTGTTGCTGTCATTGCAGGCGGTTAACGCTAAAGACAA
GCAACAACTGTGGCTGGCATCGGACAGCATGGGCGATGACGAGTGGCGCCATCTACGTCAGCTTCTTTTGCAGCAGAAAC
ACTGGGCGAGATAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9796.01 Da
• Isoelectric Point: 4.6112

>AT152872 WP_001165438.1 NZ_CP050432:2743408-2743671 [Acinetobacter baumannii]
MQIFTYTDARNNLKTVLDRVIDDSDVAVITRKEGQHAVVMGQDYYNSIMETLHLMSSPSNAAHLAKSIAELRASKAIERE
LLDETED

Nucleotide

• Length: 264 bp

>AT152872 NZ_CP066552:c4114054-4113788 [Pectobacterium carotovorum]
ATGGAAATCGATAATAAATCACGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAATTGGATATCGCGATCATGCCGTT
TTTTGAGCATGACTATGACACACTTAATGATACTGATAAGCGTACGTTTGTACGTTTGTTACAAAGCGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGTGAGCCGGAAGACGGAGAGCTGAGACACATGATTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCAATGTGA

Structures

Toxin

• AlphaFold DB: A0A4Q4HKU6