Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 2700926..2702667 Replicon chromosome
Accession NZ_CP050432
Organism Acinetobacter baumannii strain PM194229

Toxin (Protein)


Gene name pmenT Uniprot ID N9S537
Locus tag HB663_RS13035 Protein ID WP_000233088.1
Coordinates 2702011..2702667 (-) Length 219 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID A0A7U4WEK7
Locus tag HB663_RS13030 Protein ID WP_000622036.1
Coordinates 2700926..2702011 (-) Length 362 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB663_RS13015 2696497..2697372 - 876 WP_000732875.1 hypothetical protein -
HB663_RS13020 2698217..2699305 + 1089 WP_001153944.1 DUF898 domain-containing protein -
HB663_RS13025 2699365..2700417 + 1053 WP_086222338.1 M48 family metallopeptidase -
HB663_RS13030 2700926..2702011 - 1086 WP_000622036.1 macro domain-containing protein Antitoxin
HB663_RS13035 2702011..2702667 - 657 WP_000233088.1 DUF4433 domain-containing protein Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(18-218)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 219 a.a.        Molecular weight: 25316.92 Da        Isoelectric Point: 7.1033

>T152871 WP_000233088.1 NZ_CP050432:c2702667-2702011 [Acinetobacter baumannii]
MVGRNYSDVLNPQKALIWRIVHRDNIPWILENGLHSSNSPTQCVNWVQIGSPELIEKRQLHPVPVGKKGVLSDYIPFYFT
PFSPMLLNIKSGRGGVRQRTNDEIVILVSSLYQLQQQQIPFVFTNSHAYYQWAEFYTDLSSLNEIDWSILQARDFKRDMD
DPAKFERYQAEALVHQHCPTKVLIGVICYTETVKAQIEQWLQQADVNIPVHVRQGVYF

Download         Length: 657 bp

>T152871 NZ_CP066552:c3788844-3788365 [Pectobacterium carotovorum]
GTGGGAATAATGGCACCTGAATTATTATTACCTCAGCATGCCGTTGTTGATTTCCGAAGTTCAGAACCGTCACTGGACGA
CTGGCTGAAGCGTAAGGCGCTCAAGAATCAAACCATTGGTGCATCACGCACTTTTGTCGTGTGTGAATCGGGTGGGAATC
AGGTTATTGGCTTTTACGCGTTGGCAACTGGTAGCGTGCAGCGCCAATCCGTATCGGGTGCGTTACGGCGCAATATGCCT
GATCTGCTGCCCGTATTAGTCTTGGGTCGTCTGGCGGTAGATGAACGTTACCAGCGCCGTGGAATTGGCGCGGGACTATT
AAAAGATGCGACCTTGCGTTCCCGGCAGGTTGCTGAACAGGTAGGGACGAAAGCGTTATTAGTTCATGCGCTGTCTGAGG
AAGCAAAAGATTTCTATCTGCATTGGGGCTTTACGCCCTCGGAAATCCAGCCTAGCGCATTGCTTCTACCACTCTGGTAA

Antitoxin


Download         Length: 362 a.a.        Molecular weight: 41025.15 Da        Isoelectric Point: 5.8156

>AT152871 WP_000622036.1 NZ_CP050432:c2702011-2700926 [Acinetobacter baumannii]
MIRYTTGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPKNMAAYSQACKAGQVTTGKMFVTETNELMGARWIINFPTK
QHWRDKSKLQWIEDGLQDLKKFIIDHQVKSIAIPPLGAGNGGLEWSRVKSKIETELSDLEYVDILIFEPTTQYQNVAKKI
GVSQLTPARAMIAELVRRYWVLGIECSLLEIQKLAWFLQRVIEQKQLPNELKLNFQANYYGPYASNLDHLLNAMDGSYLK
SDKRIPDCDPLDVIWFNDQQKSKVQGYLISEAKEYMAAVEGAATLIEGFESPFGMELLATVDWLIYKEGYQPNVESIQEG
LANWSAGERWARRKSDLFKAEHIQFALQKLDGFAYSYPDVT

Download         Length: 1086 bp

>AT152871 NZ_CP066552:c3789107-3788835 [Pectobacterium carotovorum]
GTGAGAACAGAAGCGAAAGAAGCGCCGATCAACATTCGGGCTAAATCATCACAACGGGAACTGATAGACGTTGCCGCGAA
GCTGCTTTCAAAGTCACGTACTGATTTTATCCTTGAGGCTGCATGTCGTGAGGCAGAAGAGGTGCTATTGGATCAACGCC
TGTTTCTGGTTGATGACTCACAATTTAATGCTTTTATTACCGCGCTGGAAAAACCTGTCGCAACCAATGAACGGTTACAG
GCGTTATTAGACAGGAAATCACCGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N9S537

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4WEK7

References