Detailed information of TA system TA152870

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1848436..1850072
• Replicon: chromosome
• Accession: NZ_CP050432
• Organism: Acinetobacter baumannii strain PM194229

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A7U4NHR9
• Locus tag: HB663_RS08935
• Protein ID: WP_000737055.1
• Coordinates: 1848436..1849767 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HB663_RS08940
• Protein ID: WP_001101310.1
• Coordinates: 1849764..1850072 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB663_RS08910	1843520..1844758	+	1239	WP_163071846.1	TolC family protein	-
HB663_RS08915	1844751..1845911	+	1161	WP_001044489.1	hypothetical protein	-
HB663_RS08920	1846038..1847009	+	972	WP_086225860.1	5'/3'-nucleotidase SurE	-
HB663_RS08925	1847021..1847665	+	645	WP_000817306.1	hypothetical protein	-
HB663_RS08930	1847700..1848140	-	441	WP_000193136.1	HD domain-containing protein	-
HB663_RS08935	1848436..1849767	+	1332	WP_000737055.1	type II toxin-antitoxin system HipA family toxin	Toxin
HB663_RS08940	1849764..1850072	+	309	WP_001101310.1	helix-turn-helix domain-containing protein	Antitoxin
HB663_RS08945	1850796..1851362	+	567	WP_001133220.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51203.28 Da
• Isoelectric Point: 4.8549

>T152870 WP_000737055.1 NZ_CP050432:1848436-1849767 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T152870 NZ_CP066552:3787597-3787884 [Pectobacterium carotovorum]
ATGTCGTACTTTCTGGATTTTGACGAACGCGCACTAAAGGAATGGCGCAAGCTGGGCGAGACTATTCGTAATCAATTCAA
AAAGAAACTGGCCGACATTCTGGATGCCCCACGTATCGAAGCCAACAAATTACGGAGTATGCCGGACTGCTACAAAATAA
AGCTGCGCTCTGCCGGTTATCGGTTGGTTTATCAGGTTCAAGATGAAAAAGTGGTGGTTTTTGTTGTGTCAGTTGGCAAA
CGTGAGCGCTCCGAAGCATATGACGATGCAATAAAAAGATTACGCTAG

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11630.54 Da
• Isoelectric Point: 9.9701

>AT152870 WP_001101310.1 NZ_CP050432:1849764-1850072 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT152870 NZ_CP066552:3787358-3787597 [Pectobacterium carotovorum]
ATGGGCAGCATTAATCTCCGTATCGATGATGATCTTAAAACACGCTCCTACGCCGCACTCGAAAAACTGGGGGTTACACC
TTCTGAAGCATTGCGCCTTACACTGGAATACATTGCTGAAAATGAACGACTTCCCTTTAAACAGGCATTACTTAGTGATG
AAGATGCTGAATTGATTGAAATTGTTCGTGAACGTCTCCGCAATCCCAAACCAGTACGCGTGACGCTGGATGATCTTTAA

Structures

Toxin

• AlphaFold DB: A0A7U4NHR9