Detailed information of TA system TA152869

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 466879..467520
• Replicon: chromosome
• Accession: NZ_CP050432
• Organism: Acinetobacter baumannii strain PM194229

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A5N0FZY3
• Locus tag: HB663_RS02290
• Protein ID: WP_000607074.1
• Coordinates: 467131..467520 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: HB663_RS02285
• Protein ID: WP_011860336.1
• Coordinates: 466879..467124 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB663_RS02265	462383..463390	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
HB663_RS02270	463409..463786	+	378	WP_001216380.1	50S ribosomal protein L17	-
HB663_RS02275	463967..465457	+	1491	WP_000415136.1	NAD(P)/FAD-dependent oxidoreductase	-
HB663_RS02280	465507..466679	-	1173	WP_001190545.1	acyl-CoA dehydrogenase family protein	-
HB663_RS02285	466879..467124	+	246	WP_011860336.1	succinate dehydrogenase assembly factor 2	Antitoxin
HB663_RS02290	467131..467520	+	390	WP_000607074.1	membrane protein	Toxin
HB663_RS02295	468290..469375	+	1086	WP_000049106.1	hypothetical protein	-
HB663_RS02300	469453..470019	+	567	WP_000651536.1	rhombosortase	-
HB663_RS02305	470207..472402	+	2196	WP_001158905.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15621.89 Da
• Isoelectric Point: 10.3890

>T152869 WP_000607074.1 NZ_CP050432:467131-467520 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T152869 NZ_CP066552:3280764-3281183 [Pectobacterium carotovorum]
ATGACAGATATTTTGCTCAACAAAAGCAGCACCATACAAAGATGCCTACGTCGTATTCGTGAGGAATTCGATACTGAGGA
AGGGTTTCGTCAAAACTTCACCAAGCAAGATTCCGTCATACTTAACATACAGCGTGCCTGCGAAGCCGCTATTGATATCG
CTAATTATCTTATCCGTATCAAGCAGCTAGGCATACCACAAAGTAGCCGCGATAGCTTCGCGCTTCTTGCTGCAAACCAG
ATTATTACGGTTGATCTGTCTGATAACTTGCAAAAAATGGTGGGATTAAGAAATATTGCCGTGCATGACTATCAGGCGCT
CAATCTGGATATTGTCATCCACGTTATTTCTCATCGTTTAAGCGACTTTGAACATTTTATCAAACAAATAGCCCGGTACA
GCGACAGCCAGCACCTTTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9842.27 Da
• Isoelectric Point: 4.9001

>AT152869 WP_011860336.1 NZ_CP050432:466879-467124 [Acinetobacter baumannii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT152869 NZ_CP066552:3280384-3280767 [Pectobacterium carotovorum]
ATGTTCGATAAGATCGTTTTGACACTGAAAAAACAGATGCCCGACATCAAAATTATTTATCTCTTTGGTTCCCAGGCTAC
AGGCAATGCCAGAGCGGACAGCGACATTGATATCGCCATCATGGCTACGAGAGCACTGGCTCCCATTGAACGCTGGGAGC
TATCTAATCAATTAGCAAAAGAAGTGGGTCATGACGTCGATCTTATCGATTTATTGCAGGCTTCAACGGTATTAAAAATG
GAGATCGTTCGTAACGGCAAGCTGCTTTATGATGCGGAAACAGCAGCGGGGGAATTTGAAATGACAACACTTTCAATGTA
CCAGCATCTGCAAAAAGAGCGTGCGGATATCATTCGTAGCTTTAATCAGGATCTAAAAGCATGA

Structures

Toxin

• AlphaFold DB: A0A5N0FZY3