Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1532..2060 Replicon plasmid pPM194122_3
Accession NZ_CP050428
Organism Acinetobacter baumannii strain PM194188

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag HB368_RS20515 Protein ID WP_000221358.1
Coordinates 1767..2060 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9B5Q7
Locus tag HB368_RS20510 Protein ID WP_000246756.1
Coordinates 1532..1777 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB368_RS20495 1..576 + 576 WP_169059681.1 helix-turn-helix domain-containing protein -
HB368_RS20500 596..739 + 144 WP_169059682.1 hypothetical protein -
HB368_RS20505 945..1373 - 429 WP_125268442.1 hypothetical protein -
HB368_RS20510 1532..1777 + 246 WP_000246756.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HB368_RS20515 1767..2060 + 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HB368_RS20520 2134..2553 + 420 WP_031380698.1 hypothetical protein -
HB368_RS20525 3299..4174 - 876 WP_087835728.1 nucleotide-binding protein -
HB368_RS20530 4158..4784 - 627 WP_140415225.1 hypothetical protein -
HB368_RS20535 4762..4944 - 183 WP_163050525.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..7695 7695


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-71)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T152867 WP_000221358.1 NZ_CP050428:1767-2060 [Acinetobacter baumannii]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T152867 NZ_CP066552:2907306-2907638 [Pectobacterium carotovorum]
ATGGTTTCTCGTTTTGTTCCTGATTCCGGCGATTTGATCTGGTTAGATTTTGATCCGGTAGTGGGGTATGAACAGGGAGG
ACATCGCCCCGCTGTTGTTCTTAGTCCTTTTCCTTATAATAATTTGACCGGAATGTGCTTATGCACCCCCTGCACAACCC
AGCGCAAAGGGTATAACTTCGAAGTCGAATTATCTGGAGACCGTGAAAGCGTGGCTCTCGCCGATCAGGTCACTTGTGTA
GATTGGCGTAATCGGAAGGCAACAAAGAAAGGCAAAGTAACAGCCGATGAGTTAGAACTCATCAGAGCAAAAGCTAAAGC
TTTGATTGGCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9235.61 Da        Isoelectric Point: 4.3142

>AT152867 WP_000246756.1 NZ_CP050428:1532-1777 [Acinetobacter baumannii]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT152867 NZ_CP066552:2907055-2907306 [Pectobacterium carotovorum]
ATGATCGATGTTCCAGTTAAAAAATGGGGAAACTCACCTGCAATACGTCTTTCCTCATCTGTTATGCAAGCGTTTGATAT
GACGTTTAACGATAGCTTTGACATGGAGATCAGGGAAACAGAAATTGCCCTGATCCCCAAGAAAAAACCCAAATATCAGT
TTACGCTGGATGAGTTGCTTGAAGGAATGACGCCTGAACATGTCCATGAGAAAGTTGATTTTGGCGCACCAGTCGGCAAG
GAGCTGCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB N9B5Q7

References