Detailed information of TA system TA152863

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 2850027..2850537
• Replicon: chromosome
• Accession: NZ_CP050425
• Organism: Acinetobacter baumannii strain PM194188

Toxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4Q4HKU6
• Locus tag: HB368_RS13790
• Protein ID: WP_000824257.1
• Coordinates: 2850274..2850537 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7S8XU62
• Locus tag: HB368_RS13785
• Protein ID: WP_001165438.1
• Coordinates: 2850027..2850290 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB368_RS13745	2845051..2845437	-	387	WP_031958396.1	hypothetical protein	-
HB368_RS13750	2845574..2845930	-	357	WP_031958395.1	hypothetical protein	-
HB368_RS13755	2846141..2846731	+	591	WP_000676432.1	DUF805 domain-containing protein	-
HB368_RS13760	2847019..2847291	-	273	WP_001172372.1	YkgJ family cysteine cluster protein	-
HB368_RS13765	2847292..2847723	-	432	WP_001118480.1	hypothetical protein	-
HB368_RS13770	2847738..2848397	-	660	Protein_2698	hypothetical protein	-
HB368_RS13775	2848412..2849410	+	999	WP_034129546.1	hypothetical protein	-
HB368_RS13780	2849407..2849673	+	267	WP_000570798.1	AlpA family phage regulatory protein	-
HB368_RS13785	2850027..2850290	+	264	WP_001165438.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HB368_RS13790	2850274..2850537	+	264	WP_000824257.1	Txe/YoeB family addiction module toxin	Toxin
HB368_RS13795	2850644..2851852	+	1209	WP_000343018.1	IS256-like element ISAba26 family transposase	-
HB368_RS13800	2852067..2853254	-	1188	WP_002036368.1	DUF4268 domain-containing protein	-
HB368_RS13805	2853354..2854562	-	1209	WP_034129567.1	integrase arm-type DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2850644..2851852	1208

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10337.91 Da
• Isoelectric Point: 9.0098

>T152863 WP_000824257.1 NZ_CP050425:2850274-2850537 [Acinetobacter baumannii]
MKRKTSFTPTAWEDYVYWQNQDKKTLKRINTLIKECLRTPFDGIGKPEPLLGDLAGLWSRRIDEKNRLVYEVTDVAITII
SCRYHYE

Nucleotide

• Length: 264 bp

>T152863 NZ_CP066552:c613686-613435 [Pectobacterium carotovorum]
ATGCGTACAATTAGCTACAGTGAAGCCCGACAAAATCTATCGGCGACCATGATGAAAACGGTCGAAGACCGTGCTCCTAT
TCTTATCACTCGACAGAATGGTGAAGCCTGCGTGCTTATGTCTCTGGAAGAGTATAACTCTCTAGAGGAAACCGCGTATT
TACTGCGTTCACCCGCCAATGCAAAAAGACTGATGAATTCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9796.01 Da
• Isoelectric Point: 4.6112

>AT152863 WP_001165438.1 NZ_CP050425:2850027-2850290 [Acinetobacter baumannii]
MQIFTYTDARNNLKTVLDRVIDDSDVAVITRKEGQHAVVMGQDYYNSIMETLHLMSSPSNAAHLAKSIAELRASKAIERE
LLDETED

Nucleotide

• Length: 264 bp

>AT152863 NZ_CP066552:c613438-613184 [Pectobacterium carotovorum]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTATCTGTACTGGCAGGACATCGATAAGCGGATGGTCAAAAAGAT
CAATGAATTAATAAAAGAAACGCGCAGAACACCTTTTGAAGGAAAAGGAAAACCAGAGCCACTTAAACATAACCTTGCAG
GTTTCTGGTCGCGCCGCATCACCGAAGAACATCGTCTGGTTTATGCCATCACCAATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA

Structures

Toxin

• AlphaFold DB: A0A4Q4HKU6