152862

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 2812631..2814372 Replicon chromosome
Accession NZ_CP050425
Organism Acinetobacter baumannii strain PM194188

Toxin (Protein)


Gene name pmenT Uniprot ID N9S537
Locus tag HB368_RS13650 Protein ID WP_000233088.1
Coordinates 2813716..2814372 (-) Length 219 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID A0A7U4WEK7
Locus tag HB368_RS13645 Protein ID WP_000622036.1
Coordinates 2812631..2813716 (-) Length 362 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB368_RS13625 2808832..2809260 + 429 Protein_2669 DUF898 family protein -
HB368_RS13630 2809270..2810295 - 1026 WP_010326927.1 IS30 family transposase -
HB368_RS13635 2810351..2811010 + 660 Protein_2671 DUF898 family protein -
HB368_RS13640 2811070..2812122 + 1053 WP_086222338.1 M48 family metallopeptidase -
HB368_RS13645 2812631..2813716 - 1086 WP_000622036.1 macro domain-containing protein Antitoxin
HB368_RS13650 2813716..2814372 - 657 WP_000233088.1 DUF4433 domain-containing protein Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2809270..2810280 1010


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(18-218)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 219 a.a.        Molecular weight: 25316.92 Da        Isoelectric Point: 7.1033

>T152862 WP_000233088.1 NZ_CP050425:c2814372-2813716 [Acinetobacter baumannii]
MVGRNYSDVLNPQKALIWRIVHRDNIPWILENGLHSSNSPTQCVNWVQIGSPELIEKRQLHPVPVGKKGVLSDYIPFYFT
PFSPMLLNIKSGRGGVRQRTNDEIVILVSSLYQLQQQQIPFVFTNSHAYYQWAEFYTDLSSLNEIDWSILQARDFKRDMD
DPAKFERYQAEALVHQHCPTKVLIGVICYTETVKAQIEQWLQQADVNIPVHVRQGVYF

Download         Length: 657 bp

>T152862 NZ_CP066552:c613438-613184 [Pectobacterium carotovorum]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTATCTGTACTGGCAGGACATCGATAAGCGGATGGTCAAAAAGAT
CAATGAATTAATAAAAGAAACGCGCAGAACACCTTTTGAAGGAAAAGGAAAACCAGAGCCACTTAAACATAACCTTGCAG
GTTTCTGGTCGCGCCGCATCACCGAAGAACATCGTCTGGTTTATGCCATCACCAATGACGCCATGATGATCGCTGCCTGC
CGCTACCACTATTAA

Antitoxin


Download         Length: 362 a.a.        Molecular weight: 41025.15 Da        Isoelectric Point: 5.8156

>AT152862 WP_000622036.1 NZ_CP050425:c2813716-2812631 [Acinetobacter baumannii]
MIRYTTGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPKNMAAYSQACKAGQVTTGKMFVTETNELMGARWIINFPTK
QHWRDKSKLQWIEDGLQDLKKFIIDHQVKSIAIPPLGAGNGGLEWSRVKSKIETELSDLEYVDILIFEPTTQYQNVAKKI
GVSQLTPARAMIAELVRRYWVLGIECSLLEIQKLAWFLQRVIEQKQLPNELKLNFQANYYGPYASNLDHLLNAMDGSYLK
SDKRIPDCDPLDVIWFNDQQKSKVQGYLISEAKEYMAAVEGAATLIEGFESPFGMELLATVDWLIYKEGYQPNVESIQEG
LANWSAGERWARRKSDLFKAEHIQFALQKLDGFAYSYPDVT

Download         Length: 1086 bp

>AT152862 NZ_CP066552:c613686-613435 [Pectobacterium carotovorum]
ATGCGTACAATTAGCTACAGTGAAGCCCGACAAAATCTATCGGCGACCATGATGAAAACGGTCGAAGACCGTGCTCCTAT
TCTTATCACTCGACAGAATGGTGAAGCCTGCGTGCTTATGTCTCTGGAAGAGTATAACTCTCTAGAGGAAACCGCGTATT
TACTGCGTTCACCCGCCAATGCAAAAAGACTGATGAATTCAATCGAGAGCCTTAAGGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N9S537

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4WEK7

References