Detailed information of TA system TA152861

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1631175..1631854
• Replicon: chromosome
• Accession: NZ_CP050425
• Organism: Acinetobacter baumannii strain PM194188

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: HB368_RS07980
• Protein ID: WP_000838146.1
• Coordinates: 1631175..1631357 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: HB368_RS07985
• Protein ID: WP_000966688.1
• Coordinates: 1631450..1631854 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB368_RS07945	1626542..1626946	+	405	WP_049592480.1	hypothetical protein	-
HB368_RS07950	1626918..1627286	+	369	WP_049592481.1	hypothetical protein	-
HB368_RS07955	1627288..1627686	+	399	WP_025469889.1	hypothetical protein	-
HB368_RS07960	1627755..1628108	+	354	WP_000064610.1	hypothetical protein	-
HB368_RS07965	1628108..1629250	+	1143	WP_169059674.1	phage tail protein	-
HB368_RS07970	1629347..1630264	+	918	WP_038346476.1	hypothetical protein	-
HB368_RS07975	1630334..1630849	+	516	WP_049592484.1	hypothetical protein	-
HB368_RS07980	1631175..1631357	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
HB368_RS07985	1631450..1631854	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HB368_RS07990	1631954..1632463	+	510	WP_000734512.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1601617..1654352	52735

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T152861 WP_000838146.1 NZ_CP050425:1631175-1631357 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T152861 NZ_CP066552:587963-588238 [Pectobacterium carotovorum]
ATGGAAATACGTTGGACGCAAAAGGCACAGGATGGCCTGGAACGTATTTATGGGTTTTTCAGTCAGTACAGTCGGCAACA
TGCTGATGAGGTGCTAGATCGCTTGATCATCGGTACCACGGGGCTTGCTGACCACCTGAGAATCGGCGTATCTCAGACAA
GATATGAACCACGCGAGGTGAGAAAGATTTTGTTTGATGATTATGACGTTCACTACGAAATTCAGCACGATACGATTTAT
ATCGTCGATCTTTGGTATACACGAGAAGATCGCTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT152861 WP_000966688.1 NZ_CP050425:1631450-1631854 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT152861 NZ_CP066552:587711-587959 [Pectobacterium carotovorum]
ATGGGACAATCAGCAAAACAGACGATCAGTGCTCAGATACCCGCCGAGCTTGCTGCTGCGGTTGAAAGCCTGGCTATTGA
ACTGGATAGATCCAAAAGTTGGGTGATAAAAGAAGCGCTGACCGCAATGATTGAAGAGAGAGAACGGCGGCATCAGCAGG
TTTTGAAAGGCCTTGCTGATGTCGATACGGGAAGGGTGGTAAGCCATGCAGATGTGATCGACTTCGCCAACAAACTGAAA
AATTCATAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6