Detailed information of TA system TA152850

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1488541..1489220
• Replicon: chromosome
• Accession: NZ_CP050415
• Organism: Acinetobacter baumannii strain PM193665

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: HB367_RS07150
• Protein ID: WP_000838146.1
• Coordinates: 1489038..1489220 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: HB367_RS07145
• Protein ID: WP_000966688.1
• Coordinates: 1488541..1488945 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB367_RS07140	1487932..1488441	-	510	WP_000734512.1	hypothetical protein	-
HB367_RS07145	1488541..1488945	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HB367_RS07150	1489038..1489220	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
HB367_RS07155	1489546..1490061	-	516	WP_049592484.1	hypothetical protein	-
HB367_RS07160	1490131..1491048	-	918	WP_169063648.1	hypothetical protein	-
HB367_RS07165	1491145..1492293	-	1149	WP_049592482.1	hypothetical protein	-
HB367_RS07170	1492293..1492646	-	354	WP_000064610.1	hypothetical protein	-
HB367_RS07175	1492715..1493113	-	399	WP_025469889.1	hypothetical protein	-
HB367_RS07180	1493115..1493483	-	369	WP_049592481.1	hypothetical protein	-
HB367_RS07185	1493455..1493859	-	405	WP_049592480.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1466043..1520146	54103

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T152850 WP_000838146.1 NZ_CP050415:c1489220-1489038 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T152850 NZ_CP066546:c133292-132993 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGATCGAGATCAAACAGACCGCGACCTTTATGGAGTGGGAAAACAGGCTCAAGGATTCCAGAGCCAGGGCGTTGATCGC
TGCGCGGATTTTTCGCCTGGCCAACGGCCTTGCCGGGGACGTGTCCCCGGTGGGCGAAGGCGTCAGCGAGTTGCGCATCC
ATTACGGGCCGGGCTACCGAGTTTATTTCCAGCAGCTTGGTTCGCAACTTGTCATTTTGTTATGCGGCGGCGACAAGAGT
CGCCAGAGCCGCGATATCGAACTGGCCAAATACCTGGCCCGTCGTTGGAGCCGATCATGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT152850 WP_000966688.1 NZ_CP050415:c1488945-1488541 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT152850 NZ_CP066546:c132996-132703 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGAACGAACCGCTATTCGACTATGACCCCGCCACGGCCTTGCGCGACCCGCAGGCCATCGCCCTGTTCATGGCGGACGC
CTTCGAGACCGGCGATGCCGGCTACATCGCCAAAGCCCTGGGCGTGGTGGCGCGGGCCAAGGGCATGACCGAACTGGCCC
ATGAAACCGGGCTGTCCCGCGAGCAGCTGTACCGCTCGTTCAGTGACAAGGGCAACCCGACCCTGAAGACCCTGCTGGCG
GTGATGCGCGCCCTGGGGCTGGATATGACGGCGCGGGTGCATGGGGCGTCTTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6