Detailed information of TA system TA152848

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 270907..271417
• Replicon: chromosome
• Accession: NZ_CP050415
• Organism: Acinetobacter baumannii strain PM193665

Toxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4Q4HKU6
• Locus tag: HB367_RS01340
• Protein ID: WP_000824257.1
• Coordinates: 270907..271170 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7S8XU62
• Locus tag: HB367_RS01345
• Protein ID: WP_001165438.1
• Coordinates: 271154..271417 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB367_RS01325	266882..268090	+	1209	WP_034129567.1	integrase arm-type DNA-binding domain-containing protein	-
HB367_RS01330	268190..269377	+	1188	WP_002036368.1	DUF4268 domain-containing protein	-
HB367_RS01335	269592..270800	-	1209	WP_000343018.1	IS256-like element ISAba26 family transposase	-
HB367_RS01340	270907..271170	-	264	WP_000824257.1	Txe/YoeB family addiction module toxin	Toxin
HB367_RS01345	271154..271417	-	264	WP_001165438.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HB367_RS01350	271771..272037	-	267	WP_000570798.1	AlpA family phage regulatory protein	-
HB367_RS01355	272034..273032	-	999	WP_034129546.1	hypothetical protein	-
HB367_RS01360	273047..273706	+	660	Protein_264	hypothetical protein	-
HB367_RS01365	273721..274152	+	432	WP_001118480.1	hypothetical protein	-
HB367_RS01370	274153..274425	+	273	WP_001172372.1	YkgJ family cysteine cluster protein	-
HB367_RS01375	274713..275303	-	591	WP_000676432.1	DUF805 domain-containing protein	-
HB367_RS01380	275514..275870	+	357	WP_031958395.1	hypothetical protein	-
HB367_RS01385	276007..276393	+	387	WP_031958396.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	268142..477360	209218
	-	flank	IS/Tn	-	-	269592..270800	1208

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10337.91 Da
• Isoelectric Point: 9.0098

>T152848 WP_000824257.1 NZ_CP050415:c271170-270907 [Acinetobacter baumannii]
MKRKTSFTPTAWEDYVYWQNQDKKTLKRINTLIKECLRTPFDGIGKPEPLLGDLAGLWSRRIDEKNRLVYEVTDVAITII
SCRYHYE

Nucleotide

• Length: 264 bp

>T152848 NZ_CP066544:76473-76889 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9796.01 Da
• Isoelectric Point: 4.6112

>AT152848 WP_001165438.1 NZ_CP050415:c271417-271154 [Acinetobacter baumannii]
MQIFTYTDARNNLKTVLDRVIDDSDVAVITRKEGQHAVVMGQDYYNSIMETLHLMSSPSNAAHLAKSIAELRASKAIERE
LLDETED

Nucleotide

• Length: 264 bp

>AT152848 NZ_CP066544:76246-76476 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: A0A4Q4HKU6