Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | BrnTA/BrnT-BrnA |
Location | 2763..3351 | Replicon | plasmid pPM192696_2 |
Accession | NZ_CP050414 | ||
Organism | Acinetobacter baumannii strain PM192696 |
Toxin (Protein)
Gene name | brnT | Uniprot ID | A0A3G6Z3M6 |
Locus tag | HB366_RS19470 | Protein ID | WP_000438826.1 |
Coordinates | 2763..3050 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | brnA | Uniprot ID | N9M5I3 |
Locus tag | HB366_RS19475 | Protein ID | WP_001983304.1 |
Coordinates | 3037..3351 (+) | Length | 105 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HB366_RS19450 | 1..951 | + | 951 | WP_001205343.1 | replication initiation protein RepM | - |
HB366_RS19455 | 944..1519 | + | 576 | WP_001096616.1 | helix-turn-helix domain-containing protein | - |
HB366_RS19460 | 1539..1682 | + | 144 | WP_001125246.1 | hypothetical protein | - |
HB366_RS19465 | 1872..2390 | - | 519 | WP_000447193.1 | sel1 repeat family protein | - |
HB366_RS19470 | 2763..3050 | + | 288 | WP_000438826.1 | BrnT family toxin | Toxin |
HB366_RS19475 | 3037..3351 | + | 315 | WP_001983304.1 | BrnA antitoxin family protein | Antitoxin |
HB366_RS19480 | 3479..5890 | + | 2412 | WP_000932953.1 | TonB-dependent receptor ZnuD2 | - |
HB366_RS19485 | 6195..6656 | + | 462 | WP_000761346.1 | DIP1984 family protein | - |
HB366_RS19490 | 6979..7152 | - | 174 | WP_001282484.1 | hypothetical protein | - |
HB366_RS19495 | 7152..7523 | - | 372 | WP_000504218.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..8732 | 8732 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11303.72 Da Isoelectric Point: 6.0889
>T152847 WP_000438826.1 NZ_CP050414:2763-3050 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG
Download Length: 288 bp
>T152847 NZ_CP066544:c19269-19120 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12208.84 Da Isoelectric Point: 7.2026
>AT152847 WP_001983304.1 NZ_CP050414:3037-3351 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ
Download Length: 315 bp
>AT152847 NZ_CP066544:19314-19373 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3G6Z3M6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | N9M5I3 |