152847

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 2763..3351 Replicon plasmid pPM192696_2
Accession NZ_CP050414
Organism Acinetobacter baumannii strain PM192696

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag HB366_RS19470 Protein ID WP_000438826.1
Coordinates 2763..3050 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag HB366_RS19475 Protein ID WP_001983304.1
Coordinates 3037..3351 (+) Length 105 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB366_RS19450 1..951 + 951 WP_001205343.1 replication initiation protein RepM -
HB366_RS19455 944..1519 + 576 WP_001096616.1 helix-turn-helix domain-containing protein -
HB366_RS19460 1539..1682 + 144 WP_001125246.1 hypothetical protein -
HB366_RS19465 1872..2390 - 519 WP_000447193.1 sel1 repeat family protein -
HB366_RS19470 2763..3050 + 288 WP_000438826.1 BrnT family toxin Toxin
HB366_RS19475 3037..3351 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
HB366_RS19480 3479..5890 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
HB366_RS19485 6195..6656 + 462 WP_000761346.1 DIP1984 family protein -
HB366_RS19490 6979..7152 - 174 WP_001282484.1 hypothetical protein -
HB366_RS19495 7152..7523 - 372 WP_000504218.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..8732 8732


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T152847 WP_000438826.1 NZ_CP050414:2763-3050 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T152847 NZ_CP066544:c19269-19120 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT152847 WP_001983304.1 NZ_CP050414:3037-3351 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT152847 NZ_CP066544:19314-19373 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6


Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References