Detailed information of TA system TA152845

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 449204..449845
• Replicon: chromosome
• Accession: NZ_CP050412
• Organism: Acinetobacter baumannii strain PM192696

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: HB366_RS02180
• Protein ID: WP_000607077.1
• Coordinates: 449456..449845 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: HB366_RS02175
• Protein ID: WP_011860336.1
• Coordinates: 449204..449449 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB366_RS02155	444708..445715	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
HB366_RS02160	445734..446111	+	378	WP_001216380.1	50S ribosomal protein L17	-
HB366_RS02165	446293..447783	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
HB366_RS02170	447832..449004	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
HB366_RS02175	449204..449449	+	246	WP_011860336.1	succinate dehydrogenase assembly factor 2	Antitoxin
HB366_RS02180	449456..449845	+	390	WP_000607077.1	membrane protein	Toxin
HB366_RS02185	450615..451700	+	1086	WP_000049106.1	hypothetical protein	-
HB366_RS02190	451778..452344	+	567	WP_000651538.1	rhombosortase	-
HB366_RS02195	452532..454727	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T152845 WP_000607077.1 NZ_CP050412:449456-449845 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T152845 NZ_CP066543:c4725116-4724748 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9842.27 Da
• Isoelectric Point: 4.9001

>AT152845 WP_011860336.1 NZ_CP050412:449204-449449 [Acinetobacter baumannii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT152845 NZ_CP066543:c4725334-4725113 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA