Detailed information of TA system TA152839

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3006374..3007056
• Replicon: chromosome
• Accession: NZ_CP050403
• Organism: Acinetobacter baumannii strain VB2486

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HBN34_RS14485
• Protein ID: WP_002077557.1
• Coordinates: 3006874..3007056 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HBN34_RS14480
• Protein ID: WP_000966687.1
• Coordinates: 3006374..3006778 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBN34_RS14450	3003097..3003423	-	327	WP_000721695.1	hypothetical protein	-
HBN34_RS14455	3003495..3004178	-	684	WP_005123868.1	hypothetical protein	-
HBN34_RS14460	3004210..3004533	-	324	WP_000523925.1	DUF4236 domain-containing protein	-
HBN34_RS14465	3004542..3004718	-	177	WP_001983384.1	hypothetical protein	-
HBN34_RS14470	3004875..3005285	-	411	WP_000064169.1	hypothetical protein	-
HBN34_RS14475	3005300..3006133	-	834	WP_000658554.1	hypothetical protein	-
HBN34_RS14480	3006374..3006778	-	405	WP_000966687.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HBN34_RS14485	3006874..3007056	-	183	WP_002077557.1	type II toxin-antitoxin system HicA family toxin	Toxin
HBN34_RS14490	3007382..3007897	-	516	WP_001185611.1	hypothetical protein	-
HBN34_RS14495	3007967..3008884	-	918	WP_000094281.1	hypothetical protein	-
HBN34_RS14500	3008979..3010076	-	1098	WP_001284998.1	hypothetical protein	-
HBN34_RS14505	3010076..3010426	-	351	WP_000064573.1	hypothetical protein	-
HBN34_RS14510	3010523..3010741	-	219	WP_001277691.1	hypothetical protein	-
HBN34_RS14515	3010743..3011186	-	444	WP_002039534.1	hypothetical protein	-
HBN34_RS14520	3011143..3011511	-	369	WP_000539744.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2940810..3032825	92015

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6709.86 Da
• Isoelectric Point: 10.5523

>T152839 WP_002077557.1 NZ_CP050403:c3007056-3006874 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVTGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T152839 NZ_CP066543:c986466-986248 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAAAAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14664.59 Da
• Isoelectric Point: 4.3543

>AT152839 WP_000966687.1 NZ_CP050403:c3006778-3006374 [Acinetobacter baumannii]
MLYPIAIERGSDNEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPEASDLSTYIDDPAYKGMIWAV
TEIDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT152839 NZ_CP066543:c986867-986493 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG