Detailed information of TA system TA152839

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3006374..3007056
• Replicon: chromosome
• Accession: NZ_CP050403
• Organism: Acinetobacter baumannii strain VB2486

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HBN34_RS14485
• Protein ID: WP_002077557.1
• Coordinates: 3006874..3007056 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HBN34_RS14480
• Protein ID: WP_000966687.1
• Coordinates: 3006374..3006778 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2940810..3032825	92015

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6709.86 Da
• Isoelectric Point: 10.5523

>T152839 WP_002077557.1 NZ_CP050403:c3007056-3006874 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVTGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T152839 NZ_CP066543:c986466-986248 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAAAAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14664.59 Da
• Isoelectric Point: 4.3543

>AT152839 WP_000966687.1 NZ_CP050403:c3006778-3006374 [Acinetobacter baumannii]
MLYPIAIERGSDNEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPEASDLSTYIDDPAYKGMIWAV
TEIDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT152839 NZ_CP066543:c986867-986493 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG