Detailed information of TA system TA152838

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1684836..1685515
• Replicon: chromosome
• Accession: NZ_CP050403
• Organism: Acinetobacter baumannii strain VB2486

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: HBN34_RS07980
• Protein ID: WP_000838146.1
• Coordinates: 1684836..1685018 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: HBN34_RS07985
• Protein ID: WP_000966688.1
• Coordinates: 1685111..1685515 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBN34_RS07940	1679880..1680248	+	369	WP_075703240.1	hypothetical protein	-
HBN34_RS07945	1680250..1680648	+	399	WP_075703241.1	hypothetical protein	-
HBN34_RS07950	1680650..1680868	+	219	WP_001277696.1	hypothetical protein	-
HBN34_RS07955	1680977..1681498	+	522	WP_000749906.1	SH3 domain-containing protein	-
HBN34_RS07960	1681595..1681948	+	354	WP_000064599.1	hypothetical protein	-
HBN34_RS07965	1681948..1682955	+	1008	WP_114673975.1	phage tail protein	-
HBN34_RS07970	1683008..1683925	+	918	WP_049582403.1	hypothetical protein	-
HBN34_RS07975	1683995..1684510	+	516	WP_114674358.1	hypothetical protein	-
HBN34_RS07980	1684836..1685018	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
HBN34_RS07985	1685111..1685515	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HBN34_RS07990	1685614..1686291	+	678	Protein_1547	hypothetical protein	-
HBN34_RS07995	1686305..1687558	-	1254	WP_000182043.1	IS256 family transposase	-
HBN34_RS08000	1687684..1687947	+	264	WP_001275792.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	plc	1622901..1715687	92786
	-	flank	IS/Tn	-	-	1686305..1687558	1253

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T152838 WP_000838146.1 NZ_CP050403:1684836-1685018 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T152838 NZ_CP066543:372435-372968 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT152838 WP_000966688.1 NZ_CP050403:1685111-1685515 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT152838 NZ_CP066543:372158-372424 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6