Detailed information of TA system TA152837

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1190713..1191232
• Replicon: chromosome
• Accession: NZ_CP050403
• Organism: Acinetobacter baumannii strain VB2486

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HBN34_RS05560
• Protein ID: WP_114673887.1
• Coordinates: 1190713..1190994 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8B5UBP1
• Locus tag: HBN34_RS05565
• Protein ID: WP_029424561.1
• Coordinates: 1190984..1191232 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBN34_RS05525	1185892..1186824	+	933	WP_000742756.1	IS5-like element ISAba12 family transposase	-
HBN34_RS05530	1186876..1187595	+	720	Protein_1063	hypothetical protein	-
HBN34_RS05535	1187612..1187821	+	210	WP_069119598.1	AlpA family transcriptional regulator	-
HBN34_RS05540	1187898..1188302	-	405	WP_069119600.1	helix-turn-helix domain-containing protein	-
HBN34_RS05545	1188717..1189259	+	543	WP_147402263.1	hypothetical protein	-
HBN34_RS05550	1189289..1190221	-	933	WP_000742756.1	IS5-like element ISAba12 family transposase	-
HBN34_RS05555	1190206..1190421	+	216	WP_169059655.1	hypothetical protein	-
HBN34_RS05560	1190713..1190994	-	282	WP_114673887.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HBN34_RS05565	1190984..1191232	-	249	WP_029424561.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HBN34_RS05570	1191235..1191639	-	405	WP_032009360.1	hypothetical protein	-
HBN34_RS05575	1191684..1192280	-	597	WP_057061462.1	recombinase family protein	-
HBN34_RS05580	1192514..1193191	+	678	WP_165961563.1	hypothetical protein	-
HBN34_RS05585	1193269..1193697	+	429	WP_000364662.1	IS66 family insertion sequence hypothetical protein	-
HBN34_RS05590	1193694..1194029	+	336	WP_120752736.1	IS66 family insertion sequence element accessory protein TnpB	-
HBN34_RS05595	1194104..1195750	+	1647	WP_127220000.1	IS66-like element ISAba17 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1182277..1192280	10003
	-	inside	IScluster/Tn	-	-	1183353..1195750	12397

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10917.69 Da
• Isoelectric Point: 10.0689

>T152837 WP_114673887.1 NZ_CP050403:c1190994-1190713 [Acinetobacter baumannii]
MSYNLDFLEEALEEWNKLNPSIKQPMKKKLMKVLENPRIPKNKLSGHPNRYKIKLRSVGYRLVYEVIDDEVVVLVIAVGR
RENNDIYNTASSR

Nucleotide

• Length: 282 bp

>T152837 NZ_CP066543:269424-269708 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9272.74 Da
• Isoelectric Point: 5.8061

>AT152837 WP_029424561.1 NZ_CP050403:c1191232-1190984 [Acinetobacter baumannii]
MTQLIHARMTASITELKKSPMDTVLAGKGEAVAILNRNTPAFYCIPADLYENMIEQLEDLELNKIADTRANQKRIRVNIN
EL

Nucleotide

• Length: 249 bp

>AT152837 NZ_CP066543:269192-269434 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A8B5UBP1