Detailed information of TA system TA152834

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1014443..1015094
• Replicon: chromosome
• Accession: NZ_CP050401
• Organism: Acinetobacter baumannii strain VB2181

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: HBM82_RS04915
• Protein ID: WP_000838146.1
• Coordinates: 1014443..1014625 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A009ITU8
• Locus tag: HBM82_RS04920
• Protein ID: WP_005070359.1
• Coordinates: 1014690..1015094 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBM82_RS04865	1009700..1010365	+	666	WP_000767881.1	stress-responsive nuclear envelope protein	-
HBM82_RS04870	1010370..1010759	+	390	WP_000008492.1	hypothetical protein	-
HBM82_RS04875	1010716..1011129	+	414	WP_071708264.1	glutamate 5-kinase	-
HBM82_RS04880	1011138..1011542	+	405	WP_046122502.1	hypothetical protein	-
HBM82_RS04885	1011514..1011882	+	369	WP_046122503.1	hypothetical protein	-
HBM82_RS04890	1011884..1012282	+	399	WP_046122504.1	hypothetical protein	-
HBM82_RS04895	1012284..1012496	+	213	WP_000121166.1	hypothetical protein	-
HBM82_RS04900	1012604..1013533	+	930	WP_046122505.1	hypothetical protein	-
HBM82_RS04905	1013578..1014111	+	534	WP_001185623.1	hypothetical protein	-
HBM82_RS18995	1014225..1014374	+	150	WP_171249566.1	hypothetical protein	-
HBM82_RS04915	1014443..1014625	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
HBM82_RS04920	1014690..1015094	+	405	WP_005070359.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HBM82_RS04925	1015175..1015576	+	402	WP_046122506.1	hypothetical protein	-
HBM82_RS04930	1015637..1019605	+	3969	WP_046122507.1	tape measure protein	-
HBM82_RS04935	1019723..1020064	+	342	WP_046122508.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	974211..1039382	65171

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T152834 WP_000838146.1 NZ_CP050401:1014443-1014625 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T152834 NZ_CP066541:1561196-1561531 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14735.72 Da
• Isoelectric Point: 4.4367

>AT152834 WP_005070359.1 NZ_CP050401:1014690-1015094 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT152834 NZ_CP066541:1560919-1561206 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: A0A009ITU8