Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2516894..2517545 Replicon chromosome
Accession NZ_CP050400
Organism Acinetobacter baumannii strain VB11737

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag HBM80_RS12675 Protein ID WP_000838146.1
Coordinates 2517363..2517545 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag HBM80_RS12670 Protein ID WP_000966689.1
Coordinates 2516894..2517298 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBM80_RS12660 2512215..2516183 - 3969 WP_000191303.1 tape measure protein -
HBM80_RS12665 2516280..2516798 - 519 WP_053530939.1 DUF4468 domain-containing protein -
HBM80_RS12670 2516894..2517298 - 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HBM80_RS12675 2517363..2517545 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
HBM80_RS12680 2517877..2518410 - 534 WP_001185622.1 hypothetical protein -
HBM80_RS12685 2518455..2519384 - 930 WP_000094300.1 hypothetical protein -
HBM80_RS12690 2519493..2519705 - 213 WP_000121166.1 hypothetical protein -
HBM80_RS12695 2519707..2520105 - 399 WP_001132270.1 hypothetical protein -
HBM80_RS12700 2520107..2520475 - 369 WP_000539752.1 hypothetical protein -
HBM80_RS12705 2520447..2520851 - 405 WP_000248324.1 hypothetical protein -
HBM80_RS12710 2520860..2521273 - 414 WP_001197735.1 hypothetical protein -
HBM80_RS12715 2521230..2521619 - 390 WP_032041498.1 hypothetical protein -
HBM80_RS12720 2521624..2522289 - 666 WP_000767881.1 stress-responsive nuclear envelope protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2496769..2546409 49640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T152831 WP_000838146.1 NZ_CP050400:c2517545-2517363 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T152831 NZ_CP066536:153736-153885 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT152831 WP_000966689.1 NZ_CP050400:c2517298-2516894 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT152831 NZ_CP066536:c153691-153632 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References