Detailed information of TA system TA152827

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 447980..448621
• Replicon: chromosome
• Accession: NZ_CP050390
• Organism: Acinetobacter baumannii strain VB723

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: HBM78_RS02180
• Protein ID: WP_000607077.1
• Coordinates: 448232..448621 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: HBM78_RS02175
• Protein ID: WP_011860336.1
• Coordinates: 447980..448225 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBM78_RS02155	443484..444491	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
HBM78_RS02160	444510..444887	+	378	WP_001216380.1	50S ribosomal protein L17	-
HBM78_RS02165	445069..446559	+	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
HBM78_RS02170	446608..447780	-	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
HBM78_RS02175	447980..448225	+	246	WP_011860336.1	succinate dehydrogenase assembly factor 2	Antitoxin
HBM78_RS02180	448232..448621	+	390	WP_000607077.1	membrane protein	Toxin
HBM78_RS02185	449391..450476	+	1086	WP_000049106.1	hypothetical protein	-
HBM78_RS02190	450554..451120	+	567	WP_000651538.1	rhombosortase	-
HBM78_RS02195	451308..453503	+	2196	WP_001158906.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T152827 WP_000607077.1 NZ_CP050390:448232-448621 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T152827 NZ_CP066534:c5386932-5386549 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9842.27 Da
• Isoelectric Point: 4.9001

>AT152827 WP_011860336.1 NZ_CP050390:447980-448225 [Acinetobacter baumannii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT152827 NZ_CP066534:c5387174-5386932 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA