Detailed information of TA system TA152821

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3245529..3246170
• Replicon: chromosome
• Accession: NZ_CP050385
• Organism: Acinetobacter baumannii strain VB82

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A3R9G864
• Locus tag: HBK86_RS15770
• Protein ID: WP_000607075.1
• Coordinates: 3245529..3245918 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: HBK86_RS15775
• Protein ID: WP_011860336.1
• Coordinates: 3245925..3246170 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBK86_RS15755	3240647..3242842	-	2196	WP_001158905.1	TRAP transporter large permease subunit	-
HBK86_RS15760	3243030..3243596	-	567	WP_000651539.1	rhombosortase	-
HBK86_RS15765	3243674..3244759	-	1086	WP_000049105.1	hypothetical protein	-
HBK86_RS15770	3245529..3245918	-	390	WP_000607075.1	membrane protein	Toxin
HBK86_RS15775	3245925..3246170	-	246	WP_011860336.1	succinate dehydrogenase assembly factor 2	Antitoxin
HBK86_RS15780	3246370..3247542	+	1173	WP_001190556.1	acyl-CoA dehydrogenase family protein	-
HBK86_RS15785	3247591..3249081	-	1491	WP_000415123.1	NAD(P)/FAD-dependent oxidoreductase	-
HBK86_RS15790	3249263..3249640	-	378	WP_001216380.1	50S ribosomal protein L17	-
HBK86_RS15795	3249659..3250666	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15649.94 Da
• Isoelectric Point: 10.3890

>T152821 WP_000607075.1 NZ_CP050385:c3245918-3245529 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLVEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T152821 NZ_CP066534:823091-823624 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9842.27 Da
• Isoelectric Point: 4.9001

>AT152821 WP_011860336.1 NZ_CP050385:c3246170-3245925 [Acinetobacter baumannii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT152821 NZ_CP066534:822814-823080 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: A0A3R9G864