Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 547244..548076 Replicon chromosome
Accession NZ_CP050382
Organism Escherichia coli strain 52148

Toxin (Protein)


Gene name yeeV Uniprot ID E3PN67
Locus tag HB638_RS02585 Protein ID WP_000854775.1
Coordinates 547244..547618 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A426P7N5
Locus tag HB638_RS02590 Protein ID WP_001285645.1
Coordinates 547708..548076 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB638_RS02555 542606..543529 - 924 WP_000535961.1 carboxylate/amino acid/amine transporter -
HB638_RS02560 543640..544824 - 1185 WP_001172898.1 sugar efflux transporter -
HB638_RS02570 545620..546462 - 843 WP_001274548.1 DUF4942 domain-containing protein -
HB638_RS02575 546547..546744 - 198 WP_000772035.1 DUF957 domain-containing protein -
HB638_RS02580 546756..547247 - 492 WP_000976825.1 hypothetical protein -
HB638_RS02585 547244..547618 - 375 WP_000854775.1 TA system toxin CbtA family protein Toxin
HB638_RS02590 547708..548076 - 369 WP_001285645.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HB638_RS02595 548087..548239 - 153 WP_000488333.1 hypothetical protein -
HB638_RS02600 548239..548460 - 222 WP_000692303.1 DUF987 domain-containing protein -
HB638_RS02605 548529..549005 - 477 WP_001318130.1 RadC family protein -
HB638_RS02610 549021..549506 - 486 WP_000213721.1 antirestriction protein -
HB638_RS02615 549598..550416 - 819 WP_001175173.1 DUF945 domain-containing protein -
HB638_RS02620 550506..550739 - 234 WP_001278284.1 DUF905 family protein -
HB638_RS02625 550745..551422 - 678 WP_001097567.1 hypothetical protein -
HB638_RS02630 551573..552253 - 681 WP_001282911.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13965.02 Da        Isoelectric Point: 8.2830

>T152790 WP_000854775.1 NZ_CP050382:c547618-547244 [Escherichia coli]
MKTLPDTLVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T152790 NZ_CP066523:c5385248-5384865 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13678.37 Da        Isoelectric Point: 5.4492

>AT152790 WP_001285645.1 NZ_CP050382:c548076-547708 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTNG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT152790 NZ_CP066523:c5385490-5385248 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3PN67

Antitoxin

Source ID Structure
AlphaFold DB A0A426P7N5

References