152786

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 141857..142379 Replicon plasmid p51015_NDM_1
Accession NZ_CP050380
Organism Klebsiella pneumoniae strain 51015

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag HB813_RS28115 Protein ID WP_004181778.1
Coordinates 141857..142141 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5Q9LM53
Locus tag HB813_RS28120 Protein ID WP_025368601.1
Coordinates 142131..142379 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB813_RS28095 137235..138361 + 1127 Protein_133 conjugal transfer protein TraG N-terminal domain-containing protein -
HB813_RS28100 138427..139653 - 1227 WP_025368604.1 transposase -
HB813_RS28105 139690..140115 + 426 WP_040120489.1 IS200/IS605 family transposase -
HB813_RS28110 140401..141627 - 1227 WP_025368602.1 transposase -
HB813_RS28115 141857..142141 - 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HB813_RS28120 142131..142379 - 249 WP_025368601.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HB813_RS28125 142670..144469 + 1800 WP_025368600.1 ATP-dependent helicase -
HB813_RS28130 144803..145789 + 987 WP_025368599.1 hypothetical protein -
HB813_RS28135 145934..146287 + 354 WP_004181774.1 hypothetical protein -
HB813_RS28140 146349..147170 + 822 WP_004026535.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul2 / armA / msr(E) / mph(E) / qnrS1 / aph(3')-VI / blaNDM-1 / dfrA5 / qacE / sul1 / mph(A) / aph(3')-Ia rmpA2 / iutA / iucD / iucC / iucB / iucA / rmpA 1..353810 353810


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T152786 WP_004181778.1 NZ_CP050380:c142141-141857 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T152786 NZ_CP066523:4189726-4189944 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8906.12 Da        Isoelectric Point: 3.8206

>AT152786 WP_025368601.1 NZ_CP050380:c142379-142131 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT152786 NZ_CP066523:4189325-4189699 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LM53

References