152771

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2716046..2717634 Replicon chromosome
Accession NZ_CP050376
Organism Klebsiella pneumoniae strain 51015

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HB813_RS13165 Protein ID WP_004179815.1
Coordinates 2716312..2717634 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HB813_RS13160 Protein ID WP_004176198.1
Coordinates 2716046..2716312 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB813_RS13135 2711196..2712119 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
HB813_RS13140 2712100..2713254 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
HB813_RS13145 2713600..2714979 + 1380 WP_004179808.1 purine permease -
HB813_RS13150 2714957..2715457 + 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HB813_RS13155 2715454..2715780 + 327 WP_002904788.1 hydroxyisourate hydrolase -
HB813_RS13160 2716046..2716312 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HB813_RS13165 2716312..2717634 + 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
HB813_RS13170 2717651..2718943 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
HB813_RS13175 2719085..2720089 - 1005 WP_004179822.1 type 1 fimbrial protein -
HB813_RS13180 2720077..2722578 - 2502 WP_020323802.1 fimbrial biogenesis outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T152771 WP_004179815.1 NZ_CP050376:2716312-2717634 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T152771 NZ_CP066517:c4870063-4869779 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT152771 WP_004176198.1 NZ_CP050376:2716046-2716312 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT152771 NZ_CP066517:c4870295-4870053 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References