Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 761726..762561 Replicon chromosome
Accession NZ_CP050376
Organism Klebsiella pneumoniae strain 51015

Toxin (Protein)


Gene name yeeV Uniprot ID A0A5E2RWI0
Locus tag HB813_RS03665 Protein ID WP_001559913.1
Coordinates 762184..762561 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A5E3EVB5
Locus tag HB813_RS03660 Protein ID WP_032408847.1
Coordinates 761726..762094 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB813_RS03630 758506..758961 + 456 WP_000581504.1 hypothetical protein -
HB813_RS03635 759040..759273 + 234 WP_001119729.1 DUF905 family protein -
HB813_RS03640 759373..760191 + 819 WP_001559911.1 DUF945 domain-containing protein -
HB813_RS03645 760283..760768 + 486 WP_032408845.1 antirestriction protein -
HB813_RS03650 760783..761259 + 477 WP_032408846.1 RadC family protein -
HB813_RS03655 761328..761549 + 222 WP_000692300.1 DUF987 domain-containing protein -
HB813_RS03660 761726..762094 + 369 WP_032408847.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HB813_RS03665 762184..762561 + 378 WP_001559913.1 TA system toxin CbtA family protein Toxin
HB813_RS03670 762558..763046 + 489 WP_001559914.1 hypothetical protein -
HB813_RS03675 763066..763263 + 198 WP_032408848.1 DUF957 domain-containing protein -
HB813_RS03680 763348..763500 + 153 WP_164713811.1 hypothetical protein -
HB813_RS03690 763947..765058 + 1112 Protein_688 IS3 family transposase -
HB813_RS03695 765075..765263 + 189 Protein_689 transposase -
HB813_RS03700 765462..766347 - 886 Protein_690 RES domain-containing protein -
HB813_RS03705 766358..767030 - 673 Protein_691 DUF4400 domain-containing protein -
HB813_RS03710 767030..767296 - 267 WP_004178415.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 743126..775091 31965


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14148.10 Da        Isoelectric Point: 7.8276

>T152767 WP_001559913.1 NZ_CP050376:762184-762561 [Klebsiella pneumoniae]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T152767 NZ_CP066517:2025554-2025656 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13682.62 Da        Isoelectric Point: 7.8398

>AT152767 WP_032408847.1 NZ_CP050376:761726-762094 [Klebsiella pneumoniae]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT152767 NZ_CP066517:c2025663-2025518 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E2RWI0

Antitoxin

Source ID Structure
AlphaFold DB A0A5E3EVB5

References