Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4932420..4933077 Replicon chromosome
Accession NZ_CP050371
Organism Klebsiella pneumoniae strain 50595

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HB637_RS24695 Protein ID WP_002916310.1
Coordinates 4932420..4932830 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HB637_RS24700 Protein ID WP_002916312.1
Coordinates 4932811..4933077 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB637_RS24675 4928420..4930153 - 1734 WP_167317574.1 single-stranded-DNA-specific exonuclease RecJ -
HB637_RS24680 4930159..4930872 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HB637_RS24685 4930895..4931791 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HB637_RS24690 4931892..4932413 + 522 WP_002916308.1 flavodoxin FldB -
HB637_RS24695 4932420..4932830 - 411 WP_002916310.1 protein YgfX Toxin
HB637_RS24700 4932811..4933077 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HB637_RS24705 4933323..4934306 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HB637_RS24710 4934457..4935116 - 660 WP_002916317.1 hemolysin III family protein -
HB637_RS24715 4935280..4935591 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
HB637_RS24720 4935641..4936369 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HB637_RS24725 4936488..4937921 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T152751 WP_002916310.1 NZ_CP050371:c4932830-4932420 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T152751 NZ_CP066492:909370-909645 [Staphylococcus aureus]
ATGGATATCGGTACAATCGTAAGAACAATTTTATTAATAGTCGCATGGATCAATCAGTTTTTAGCAATCAATCATATTTC
TCCAATCCCAGTTGATGAAGTGTTTATAAGCACAGTCGTTACTGGGATTGTTTCAATTTGGACGTGGTGGAAGAACAACA
ACTTTACTCACGCATCTAAGAAGGGACAACAAAAAATCTATGAAGTAAAAGCTGGCATTCAGTCAACTGGTGGCGTACCT
AAAGTGAACGGAGATGATAATAATGCCGTCGGTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT152751 WP_002916312.1 NZ_CP050371:c4933077-4932811 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT152751 NZ_CP066492:c909321-909229 [Staphylococcus aureus]
ATTTGATATTTATTTTATAGTGTGTTAATTTATAGAAAAGGGAAACATGCGTAAACATGTCACCCTAATGAGCCCGTTAA
AAAGACGGTGGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References