Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3137684..3139272 Replicon chromosome
Accession NZ_CP050371
Organism Klebsiella pneumoniae strain 50595

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag HB637_RS15675 Protein ID WP_004199851.1
Coordinates 3137950..3139272 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag HB637_RS15670 Protein ID WP_002904790.1
Coordinates 3137684..3137950 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB637_RS15645 3132834..3133757 + 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -
HB637_RS15650 3133738..3134892 - 1155 WP_167317535.1 FAD-dependent urate hydroxylase HpxO -
HB637_RS15655 3135238..3136617 + 1380 WP_004199850.1 purine permease -
HB637_RS15660 3136595..3137095 + 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HB637_RS15665 3137092..3137418 + 327 WP_002904788.1 hydroxyisourate hydrolase -
HB637_RS15670 3137684..3137950 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HB637_RS15675 3137950..3139272 + 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
HB637_RS15680 3139289..3140581 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
HB637_RS15685 3140714..3141718 - 1005 WP_004199852.1 type 1 fimbrial protein -
HB637_RS15690 3141706..3144207 - 2502 WP_004199853.1 fimbrial biogenesis outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T152742 WP_004199851.1 NZ_CP050371:3137950-3139272 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T152742 NZ_CP066488:1963920-1964384 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTGCTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAACGTGGTTTATCAGATAGGGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCACATAGTAAACTTACATACGGTGATATAGGCGATTACTCGAAGTTTAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATTTCGGCTGTTCCATTACGCGAGATTGTAGAAGCATACAATTATGGCGTACGTAGCTTGTATGAGTT
GTCTGAGTATCTACAATTAAGTGAAGAATACATATTGGAGGCGATAGAACAATATAAAAAGATATACGGTATTGGTACCC
ACTACGGCGAATATTCAATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT152742 WP_002904790.1 NZ_CP050371:3137684-3137950 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT152742 NZ_CP066488:1963584-1963907 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTTTGCAGATTATATAAGAAGTAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References