Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1736111..1736730 Replicon chromosome
Accession NZ_CP050371
Organism Klebsiella pneumoniae strain 50595

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HB637_RS08520 Protein ID WP_002892050.1
Coordinates 1736111..1736329 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HB637_RS08525 Protein ID WP_002892066.1
Coordinates 1736356..1736730 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB637_RS08485 1732158..1732421 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
HB637_RS08490 1732421..1732561 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HB637_RS08495 1732558..1733256 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
HB637_RS08500 1733357..1734808 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HB637_RS08505 1734783..1735253 - 471 WP_002892026.1 YlaC family protein -
HB637_RS08510 1735274..1735414 + 141 WP_004147370.1 hypothetical protein -
HB637_RS08515 1735386..1735952 - 567 WP_002892030.1 maltose O-acetyltransferase -
HB637_RS08520 1736111..1736329 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HB637_RS08525 1736356..1736730 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HB637_RS08530 1737216..1740362 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HB637_RS08535 1740385..1741578 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T152741 WP_002892050.1 NZ_CP050371:c1736329-1736111 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T152741 NZ_CP066488:1889170-1889265 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT152741 WP_002892066.1 NZ_CP050371:c1736730-1736356 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT152741 NZ_CP066488:c1889352-1889293 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References