Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1021419..1021935 Replicon chromosome
Accession NZ_CP050371
Organism Klebsiella pneumoniae strain 50595

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag HB637_RS05015 Protein ID WP_002886902.1
Coordinates 1021651..1021935 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HB637_RS05010 Protein ID WP_002886901.1
Coordinates 1021419..1021661 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB637_RS04995 1017448..1018188 + 741 WP_002886899.1 KDGP aldolase family protein -
HB637_RS05000 1018254..1019408 + 1155 WP_002886900.1 lactonase family protein -
HB637_RS05005 1019431..1021341 + 1911 WP_004152270.1 BglG family transcription antiterminator -
HB637_RS05010 1021419..1021661 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HB637_RS05015 1021651..1021935 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HB637_RS05020 1021939..1022403 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HB637_RS05025 1022644..1024782 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
HB637_RS05030 1025139..1025882 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HB637_RS05035 1025885..1026058 - 174 WP_002886906.1 hypothetical protein -
HB637_RS05040 1026143..1026451 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T152739 WP_002886902.1 NZ_CP050371:1021651-1021935 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T152739 NZ_CP066483:27108-27365 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT152739 WP_002886901.1 NZ_CP050371:1021419-1021661 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT152739 NZ_CP066483:26846-27115 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References