Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4917453..4918072 Replicon chromosome
Accession NZ_CP050360
Organism Klebsiella pneumoniae strain 47733

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HB636_RS24545 Protein ID WP_002892050.1
Coordinates 4917453..4917671 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HB636_RS24550 Protein ID WP_002892066.1
Coordinates 4917698..4918072 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB636_RS24510 4913496..4913759 + 264 WP_032432663.1 type B 50S ribosomal protein L31 -
HB636_RS24515 4913759..4913899 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HB636_RS24520 4913896..4914594 - 699 WP_023287311.1 GNAT family N-acetyltransferase -
HB636_RS24525 4914695..4916146 + 1452 WP_004183206.1 PLP-dependent aminotransferase family protein -
HB636_RS24530 4916121..4916591 - 471 WP_020802585.1 YlaC family protein -
HB636_RS24535 4916612..4916752 + 141 WP_004147370.1 hypothetical protein -
HB636_RS24540 4916724..4917290 - 567 WP_002892030.1 maltose O-acetyltransferase -
HB636_RS24545 4917453..4917671 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HB636_RS24550 4917698..4918072 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HB636_RS24555 4918558..4921704 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HB636_RS24560 4921727..4922920 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T152728 WP_002892050.1 NZ_CP050360:c4917671-4917453 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T152728 NZ_CP066466:517356-517697 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT152728 WP_002892066.1 NZ_CP050360:c4918072-4917698 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT152728 NZ_CP066466:517126-517356 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References