Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2775037..2775694 Replicon chromosome
Accession NZ_CP050360
Organism Klebsiella pneumoniae strain 47733

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HB636_RS13910 Protein ID WP_002916310.1
Coordinates 2775037..2775447 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HB636_RS13915 Protein ID WP_002916312.1
Coordinates 2775428..2775694 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB636_RS13890 2771037..2772770 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
HB636_RS13895 2772776..2773489 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HB636_RS13900 2773512..2774408 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HB636_RS13905 2774509..2775030 + 522 WP_004144730.1 flavodoxin FldB -
HB636_RS13910 2775037..2775447 - 411 WP_002916310.1 protein YgfX Toxin
HB636_RS13915 2775428..2775694 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HB636_RS13920 2775940..2776923 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HB636_RS13925 2777074..2777733 - 660 WP_002916317.1 hemolysin III family protein -
HB636_RS13930 2777897..2778208 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HB636_RS13935 2778258..2778986 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HB636_RS13940 2779105..2780538 + 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T152721 WP_002916310.1 NZ_CP050360:c2775447-2775037 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T152721 NZ_CP066454:37406-37663 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT152721 WP_002916312.1 NZ_CP050360:c2775694-2775428 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT152721 NZ_CP066454:37144-37413 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References