Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 2114315..2114958 Replicon chromosome
Accession NZ_CP050360
Organism Klebsiella pneumoniae strain 47733

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag HB636_RS10570 Protein ID WP_032433387.1
Coordinates 2114315..2114731 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag HB636_RS10575 Protein ID WP_001261276.1
Coordinates 2114728..2114958 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB636_RS10540 2109484..2109687 - 204 WP_032433376.1 hemolysin expression modulator Hha -
HB636_RS10545 2109747..2110238 - 492 WP_032433378.1 hypothetical protein -
HB636_RS10550 2110269..2110787 - 519 WP_045326794.1 hypothetical protein -
HB636_RS10555 2110846..2111094 - 249 WP_032433382.1 hypothetical protein -
HB636_RS10560 2111413..2112984 + 1572 WP_032433383.1 ATP-binding protein -
HB636_RS10565 2113179..2114159 - 981 WP_032433385.1 hypothetical protein -
HB636_RS10570 2114315..2114731 - 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
HB636_RS10575 2114728..2114958 - 231 WP_001261276.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HB636_RS10580 2115263..2116078 + 816 WP_032433388.1 hypothetical protein -
HB636_RS10585 2116606..2118846 - 2241 WP_045326788.1 NTPase -
HB636_RS10590 2118849..2119936 - 1088 Protein_2051 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2085811..2130322 44511


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T152720 WP_032433387.1 NZ_CP050360:c2114731-2114315 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

>T152720 NZ_CP066453:46706-46828 [Enterococcus faecium]
ATGAAAGGAGTAAGCCTTTTGTCCGCATATGAGACAATTCAAACCATTCTTGGTTTTGGTATGTTTACCATTGCTTTGAT
TAGTTTGATTGTAAATATGCTTAAAAATGACAAAAAGAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT152720 WP_001261276.1 NZ_CP050360:c2114958-2114728 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT152720 NZ_CP066453:c46911-46810 [Enterococcus faecium]
CCCTCATTAACAGCACCGTTTAAAGAACGGCGGCTCAGATTAATTATTTATTGAGAAATAACCGATCCTCGCTAAAGTGA
CGGTTATTTCTTTTTGTCATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References