Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4877403..4877919 Replicon chromosome
Accession NZ_CP050354
Organism Klebsiella pneumoniae strain ZRKP01

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag HB786_RS24040 Protein ID WP_002886902.1
Coordinates 4877403..4877687 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HB786_RS24045 Protein ID WP_002886901.1
Coordinates 4877677..4877919 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HB786_RS24015 4872887..4873195 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
HB786_RS24020 4873280..4873453 + 174 WP_002886906.1 hypothetical protein -
HB786_RS24025 4873456..4874199 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HB786_RS24030 4874556..4876694 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
HB786_RS24035 4876935..4877399 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HB786_RS24040 4877403..4877687 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HB786_RS24045 4877677..4877919 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HB786_RS24050 4877997..4879907 - 1911 WP_004152270.1 BglG family transcription antiterminator -
HB786_RS24055 4879930..4881084 - 1155 WP_002886900.1 lactonase family protein -
HB786_RS24060 4881150..4881890 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T152703 WP_002886902.1 NZ_CP050354:c4877687-4877403 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T152703 NZ_CP066422:c136224-135952 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACATATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT152703 WP_002886901.1 NZ_CP050354:c4877919-4877677 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT152703 NZ_CP066422:c136487-136224 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTTGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References